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Peripheral nerve regeneration: autologous conduit of vein plus perineurium

  • Experimental Study
  • Published:
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Abstract

A new method to enhance peripheral nerve regeneration is described. A 2-cm-long segment of right sciatic nerve of 90 Sprague-Dawley rats was transected and the gap was then bridged using one of the three methods: group 1 (treated, n 1 = 30), a 2-cm-long strip of perineurium inserted inside a 2-cm-long vein graft; group 2 (control, n 2 = 30), a vein graft alone; group 3 (standard nerve graft, n 3 = 30), a resected segment of the sciatic nerve. Clinical and electrophysiological tests and quantitative analysis carried out 12 weeks after surgical procedure showed a good nerve regeneration for the treated and the control vein group, although it was lower than the standard nerve graft group. G factor values, index of nervous myelinization, were not significantly different between groups 1 and 3 (P < 0.05), but either were significantly lower than that of group 2.

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Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, Marche Polytechnic University, Via Conca, 71, 60020, Ancona, Italy

    G. Di Benedetto, L. Grassetti & A. Bertani

  2. Department of Pathology, Marche Polytechnic University, Ancona, Italy

    R. Mazzucchelli & M. Scarpelli

Authors
  1. G. Di Benedetto
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  2. L. Grassetti
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  3. R. Mazzucchelli
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  4. M. Scarpelli
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  5. A. Bertani
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Correspondence to G. Di Benedetto.

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Di Benedetto, G., Grassetti, L., Mazzucchelli, R. et al. Peripheral nerve regeneration: autologous conduit of vein plus perineurium. Eur J Plast Surg 32, 33–36 (2009). https://doi.org/10.1007/s00238-008-0302-7

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  • DOI: https://doi.org/10.1007/s00238-008-0302-7

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