Skip to main content

Advertisement

SpringerLink
Log in

The effects of acellular dermal allograft (AlloDerm®) interface on silicone-related capsule formation—experimental study

  • Experimental Study
  • Published:
European Journal of Plastic Surgery Aims and scope Submit manuscript

Abstract

The effects of acellular dermal graft (AlloDerm®) use on capsular formation due to silicone were studied. Twenty New Zealand rabbits, weighing 2,500–3,000 g, were used in the study. Textured silicone membrane fragments, 2 × 1 cm in size and wrapped with AlloDerm®, were placed subcutaneously in right thoracodorsal regions in the experiment group, composed of ten subjects. In the control group of ten subjects, the naked fragments were inserted into the same locations in left thoracodorsal regions. After a period of 12 weeks, implants, fascia, subcutaneous tissue, and skin were removed en bloc from both groups and examined macroscopically and histopathologically in terms of adhesions to surrounding tissues, capsule thickness, structural properties, the amount of fibroblasts and myofibroblasts, histiocytes, polymorphonuclear leucocytes, and lymphocytes. Statistical analysis of the histopathologic findings was done using Student’s T test. The capsule in the experiment group was found to be thinner and less cellular; this related to fibroblasts and myofibroblasts in comparison to the control group.Preliminary findings in utilizing acellular dermal allograft (AlloDerm®) as a wrap around the implant have shown positive results in minimizing the capsular formation and the possibility of further capsular contraction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Sclafani AP, McCormick SAŞ, Cocker R (2002) Biophysical and microscopic analysis of homologous dermal and fascial materials for aesthetic and reconstructive uses. Arch Facial Plast Surg 4(3):164–171

    Article  PubMed  Google Scholar 

  2. Burres SA (1998) Scar recollagenation. Laryngoscope 108:1394–1397

    Article  PubMed  Google Scholar 

  3. Arnold SB, Valerie JA (1997) Implant materials. In: Grabb WC, Smith JW (eds) Plastic surgery: general principles, chapter 4. Lippincott-Raven, Philadelphia, p 39–46

    Google Scholar 

  4. J Flood PC, Hobar (1995) Implantation: Bone, cartilage and alloplastics. Selected Readings Plast Surg 8:31–33

    Google Scholar 

  5. Ralph EH (1990) Alloplastic implants. In: Mc Carthy J (ed) Plastic surgery: general principles, chapter 20, vol. I. Saunders, Philadelphia, pp 698–732

    Google Scholar 

  6. Skillman JM, Ahmed OA, Rowsell AR (2000) Incidental improvement of breast capsular contracture following treatment of arthritis with glucosamine and chondroitin. Br J Plast Surg 56:454

    Google Scholar 

  7. Livesey S, Atkinson Y, Call T, Griffey S, Nag A (1994) An acellular dermal transplant processed from human allograft skin retains normal extracellular matrix components and ultrastructural characteristics. In AATB Conference. 20–24 August

  8. Jones FR, Schwartz BM (1996) Use of a nonimmunogenic acellular dermal allograft for soft tissue augmentation: a preliminary report. Aesthet Surg Q 16(3):196–201

    Google Scholar 

  9. Prantl L, Schreml S, Fichtner-Feigl S, Poppl N, Eisenmann-Klein M, Schwarze H, Fuchtmeier B (2007) Clinical and morphological conditions in capsular contracture formed around silicone breast implants. Plast Reconstr Surg Jul 120(1):275–284

    Google Scholar 

  10. Rudolph R, Jerrold A, Woodward M (1978) Myofibroblasts and free silicone around breast implants. Plast Reconstr Surg 62:185–195

    Article  Google Scholar 

  11. La Trenta GS (1994) Breast augmentation. In: Ree TD (ed) Aesthetic plastic surgery, chapter 35. vol. 2. Saunders, Philadelphia, p 1003–1058

    Google Scholar 

  12. Barton FE (1994) Augmentation mammaplasty. Selected Readings Plast Surg 7:9–10

    Google Scholar 

  13. Oymak O (1992) Breast prosthesis. OPC, Istanbul, p 9–11, 15–23, 31–47, 65–77 (Turkish)

    Google Scholar 

  14. Frangou J, Kanellaki M (2001) The effect of local application of mitomycin-C on the development of capsule around silicone implants in the breast: an experimental study in mice. Aesthet Plast Surg 25:118–128

    Article  Google Scholar 

  15. Cek DI, Perk C, Ozcan G (1992) Histologic changes in capsule formation around silicone implants after a single dose injection of amniotic fluid. Eur J Plast Surg 15(6):289–291

    Google Scholar 

  16. Unlu RE, Yilmaz AD, Orbay H, Can B, Tekdemir I, Sensoz O (2007) Influence of rifampin on capsule formation around silicone implants in a rat model. Aesthet Plast Surg Jul–Aug 31(4):358–364

    Google Scholar 

  17. Ibrahim Canter H, Konas E, Bozdogan O, Vargel I, Ozbatir B, Oner F, Erk Y (2007) Effect of slow release 5-fluorouracil on capsule formation around silicone breast implants: an experimental study with mice. Aesthet Plast Surg 31(6):674–679 Jun 19 [Epub ahead of print]

    Article  Google Scholar 

  18. Vinnik CA (1976) Spherical contracture of fibrous capsules around breast implants. Plast Reconstr Surg 58:555–560

    Article  PubMed  Google Scholar 

  19. Vacanti FX (2004) PHEMA as a fibrous capsule-resistant breast prosthesis. Plast Reconstr Surg 113(3):949–952

    Article  PubMed  Google Scholar 

  20. Pranti L, Poppl N, Ulrich D, Eisenmann-Klein M (2005) Hyaluronan in sera: a prognostic marker for patients with capsular contracture after aesthetical breast augmentation with smooth silicon gel implants. In 10th Congress ESPRAS 2005. Abstract book pp 118, Vienna

  21. Graaf RM, Bernades A, Rippel R, Araujo LR, Damasio RC, Auersvald A (2003) . Subfascial breast implant: A new procedure. Plast Reconstr Surg 111:904

    Article  Google Scholar 

  22. Vagedis GK (2005) A new pocket for breast augmentation: subfascial technique. In 10th Congress ESPRAS 2005. Abstract book pp 117, Vienna

  23. Dincler MS (2004) The effects of fascial tissue on capsular formation related silicon implants. In XXXIXth Congress of the European Society For Surgical Research. 12–15 May, Athens, Greece. Abstract book no. 141, pp 55

  24. Das SK, Davidson SF, Walker BL (1990) The fate of free autogenous fascial grafts in the rabbit. Br J Plast Surg 315:317

    Google Scholar 

  25. Abenavoli FM, Corelli R (2001) About AlloDerm. Plast Reconstr Surg 108(7):2175–2176

    PubMed  Google Scholar 

  26. Karacaoglu E (2005) Implant based breast surgery. In 10th Congress ESPRAS 2005. Abstract book pp 118, Vienna

  27. Van Bilsen PH, Papa ER, Brouwer LA, Vincent J, Taylor CE, DeLeij LF (2004) Ongoing foreign body reaction to subcutaneous implanted (heparin) modified Dacron in rats. J Biomed Mater Res 68A(3):423–427

    Article  Google Scholar 

Download references

Acknowledgements

We would like to thank Dr. Onder Peker for his invaluable efforts in histopathologic investigations. We also appreciate Dr. Burak Iyigun for his efforts in statistical analysis and Electron Medical, Istanbul/Turquie for their AlloDerm®-providing support.

Author information

Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, Haydarpasa Numune Teaching and Research Hospital, Istanbul, Turkey

    Adnan Uzunismail, Ali Duman, Hasan Findik & Gokhan Beyhan

  2. Department of Surgery, Veterinary Faculty, Istanbul University, Serencebey yokusu, Servet Apt No:39/23, Besiktas, 34668, Istanbul, Turkey

    Cem Perk

  3. Haydarpasa Numune Hastanesi, Plastik Ve Rekonstruktif Cerrahi Klinigi, Uskudar, Istanbul, Turkey

    Gokhan Beyhan

Authors
  1. Adnan Uzunismail
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ali Duman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Cem Perk
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hasan Findik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Gokhan Beyhan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gokhan Beyhan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uzunismail, A., Duman, A., Perk, C. et al. The effects of acellular dermal allograft (AlloDerm®) interface on silicone-related capsule formation—experimental study. Eur J Plast Surg 31, 179–185 (2008). https://doi.org/10.1007/s00238-008-0222-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00238-008-0222-6

Keywords

Search

Navigation