Abstract
Pilomatrixoma is a skin appendage tumor, which is manifested as a firm, solitary lesion. It usually measures 0.5–3.0 cm in diameter and is typically found in young people. A 31-year-old woman presented with a giant tumor of the upper dorsal region. On preoperative examination, the tumor seemed to be a malignant soft tissue tumor. It was totally excised, and the resultant defect was repaired with a latissimus dorsi musculocutaneous flap. On pathological examination, the tumor was confined to the subcutaneous layer and was composed of basophilic and shadow cells. Signs of atypia in basophilic cells present in the tumor were minimal. The tumor was consequently diagnosed as benign pilomatrixoma. The number of reported cases of pilomatrixoma larger than 10 cm in diameter is very small. This case is therefore presented as a rare case of pilomatrixoma.
References
Chiraramonti A, Gilor RS (1978) Pilomatrixoma associated with myotonic dystrophy. Arch Dermatol 46:391–408
Rothman D, Kendall AB, Baldi A (1976) A giant pilomatrixoma (Malherbe calcifying epithelioma). Arch Surg 111:86–87
Forbis R, Helwig EB (1961) Pilomatrixoma (calcifying epithelioma). Arch Dermatol 83:606–618
Gromiko N (1927) Zur Kenntnis der Bosartigen unwandlung des Verkalkten Hautepitheliomas. Arch Pathol Anat 265:103–116
Hassoku M, Tuji H, Kawanishi T (1991) A case of giant pilomatrixoma. J Chubu Jpn Orthop Traumatol 34:356
Headington JT (1976) Tumors of the hair follicle. Am J Pathol 85:479–514
Askar I, Aytekin S, Buyukbayram H (2002) Giant pilomatrixoma. Eur J Plast Surg 25:26–28
Ichikawa T, Nakajima Y, Fujimoto H, Koyama A, Honma M (1997) Giant calcifying epithelioma of Malherbe (pilomatrixoma): imaging features. Skelet Radiol 26:602–605
Ismail W, Pain S, al-Okati D, al-Sewan M (2000) Giant pilomatrixoma simulating carcinoma of the male breast. Int J Clin Pract 54:55–56
Itoh Y, Chishiki M, Ishibashi A (1998) A giant peduncular pilomatrixoma. Ann Plast Surg 41:337–338
Rosai J (2004) Rosai and Ackerman’s surgical pathology, 9th edn. Mosby, Edinburgh, pp 153–154
Kaddu S, Soyer HP, Wolf IH, Kerl H (1997) Proliferating pilomatrixoma. A histopathologic simulator of metrical carcinoma. J Cutan Pathol 24:228–234
Lazar AJ, Calonie E, Grayson W, Dei Tos AP, Mihm MC Jr, Redston M, McKee PH (2005) Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin. J Cutan Pathol 32:148–157
Lever WF, Schaumburg Lever G (1997) Histopathology of the skin, 8th edn. JB Lippincott, Philadelphia, pp 757–759
Lopansri S, Mihm MC Jr (1980) Pilomatrix carcinoma or calcifying epitheliocarcinoma of Malherbe. Cancer 45:2368–2373
Malherbe A, Chenantais J (1880) Note sur l’epitheliome calcifie des glandes sebacees. Prog Med 8:826–828
Miyamoto H, Nakanishi H, Matumoto K (1996) Giant pilomatrixoma. Jpn J Clin Dermatol 38:1154–1155
Moehlenbeck FW (1973) Pilomatrixoma (calcifying epithelioma): a statistical study. Arch Dermatol 108:532–534
Swaizumi M, Maruyama Y (1997) Sliding shape-designed latissimus dorsi flap. Ann Plast Surg 38:41–45
Takahashi T, Nomoto S, Yamada S (1999) A case of giant multiple pilomatrixomas associated with myotonic dystrophy. Jpn J Dermatol 109:434
Yamamoto H, Okubo T, Shirado M (1993) A case of giant pilomatrixoma assuming the appearance of a granuloma. Jpn J Clin Dermatol 35:1134–1135
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This article was presented at the 47th Scientific Meeting of the Japan Society of Plastic and Reconstructive Surgery, April 2004, Tokyo, Japan.
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Inami, K., Onishi, K. & Maruyama, Y. Giant pilomatrixoma looks like a malignant soft tissue tumor: a case report. Eur J Plast Surg 28, 525–528 (2006). https://doi.org/10.1007/s00238-005-0012-3
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DOI: https://doi.org/10.1007/s00238-005-0012-3