Abstract
The localization and the expression level of M-cadherin in skeletal muscle was investigated following nerve injury. The rats used in the study, in which the sciatic nerves were cut, were divided into two groups; the nerve was sutured (sutured group) or not sutured (unsutured group). In both groups, the level of M-cadherin expression decreased after the first postoperative week. The decreased level returned to the control level in the sutured group, but it did not return to the control level in the unsutured group. Immunofluorescence staining was observed around the muscular membrane at the 9th, 12th, 16th, 20th, and 24th postoperative weeks in the sutured group. These results suggest that M-cadherin plays a role in maintaining intercellular adhesion around the muscular membrane.
Similar content being viewed by others
References
Bornemann A, Schmalbruch H (1994) Immunocytochemistry of M-cadherin in mature and regenerating rat muscle. Anat Rec 239:119–125
Cifuentes DC, Nicolet M, Alameddine H, Goudou D, Dehaupas M, Rieger F, Mege RM (1995) M-cadherin localization in developing adult and regenerating mouse skeletal muscle: possible involvement in secondary myogenesis. Mech Develop 50:85–97
Grounds MD (1991) Towards understanding skeletal muscle regeneration. Pathol Res Pract 187:1–22
Irintchev M, Zeschnigk M, Powitz AS, Wernig A (1994) Expression patterns of M-cadherin in normal, degenerating, and degenerating/regenerating mouse muscles. Dev Dynam 199:326–337
Kaufmann U, Martin B, Link D, Witt K, Zeiter R, Reinhard S, Starzinski PA (1999) M-cadherin and its sisters in development of striated muscle. Cell Tissue Res 296:191–198
Moore R, Walsh FS (1993) The cell adhesion molecule M-cadherin is specifically expressed in developing and regenerating, but not denervated skeletal muscle. Development 117:1409–1420
Schmalbruch H, Lewis DM, Bcir MB (2000) Dynamics of nuclei of muscle fibers and connective tissue cells in normal and dennervated rat muscles. Muscle Nerve 23:617–626
Acknowledgement
This work was supported in part by a research grant from the Ministry of Education, Science and Culture of Japan (Grant No.14571717).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Niitsuma, K., Hatoko, M., Kuwahara, M. et al. Differential changes in the expression level of M-Cadherin in denervation and reinnervation processes following nerve injury. Eur J Plast Surg 27, 327–331 (2005). https://doi.org/10.1007/s00238-004-0702-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00238-004-0702-2