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Differentiation of radiation necrosis from tumor progression using proton magnetic resonance spectroscopy

  • Diagnostic Neuroradiology
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Abstract.

We report on a young woman who was treated by stereotactic radiotherapy for recurrence of an initially resected low-grade astrocytoma. MRI follow-up examination 7 months after radiotherapy showed a gadolinium-DTPA-enhancing mass lesion indicative of high-grade tumor progression. This assumption was also supported by positron emission tomography with [2-18F]fluoro-2-deoxy-D–glucose (FDG-PET). In contrast, proton MR spectroscopy (1H-MRS) indicated radiation necrosis, which was confirmed histopathologically in surgical specimens. Subsequent follow-up examinations up to 19 months after surgery showed no evidence of tumor recurrence.

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Authors and Affiliations

  1. Research Program Radiological Diagnostics and Therapy, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany, Germany

    H.-P. Schlemmer, P. Bachert & G. van Kaick

  2. Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany, Germany

    M. Henze

  3. Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany, Germany

    R. Buslei

  4. Radiological Clinic, University of Heidelberg, Heidelberg, Germany, Germany

    K. Herfarth & J. Debus

Authors
  1. H.-P. Schlemmer
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  2. P. Bachert
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  3. M. Henze
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  4. R. Buslei
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  5. K. Herfarth
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  6. J. Debus
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  7. G. van Kaick
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Schlemmer, HP., Bachert, P., Henze, M. et al. Differentiation of radiation necrosis from tumor progression using proton magnetic resonance spectroscopy. Neuroradiology 44, 216–222 (2002). https://doi.org/10.1007/s002340100703

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  • DOI: https://doi.org/10.1007/s002340100703

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