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Reply: assessing the effect of oral glutamine on the MELAS phenotype requires appropriate study designs

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Data is available on request from the authors.

References

  1. Guerrero-Molina MP, Bernabeu-Sanz Á, Ramos-González A, Morales-Conejo M, Delmiro A, Domínguez-González C, Arenas J, Martín MA, González de la Aleja J (2019) Magnetic resonance spectroscopy in MELAS syndrome: correlation with CSF and plasma metabolite levels and change after glutamine supplementation. Neuroradiology https://doi.org/10.1007/s00234-023-03263-1

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Funding

This research was supported by a grant from the Spanish Fundación Eugenio Rodríguez Pascual and the Fundación Mutua Madrileña. The financial sponsors had no role in the analysis or the development of conclusions. The investigators are solely responsible for the content and the decision to submit the manuscript for publication.

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Authors and Affiliations

  1. Neurology Department, Neuromuscular Disorders Unit, University Hospital, 12 de Octubre, Madrid, Spain

    María Paz Guerrero-Molina

  2. Neurology Department, Epilepsy Unit, University Hospital, 12 de Octubre, Madrid, Spain

    Jesús González de la Aleja

Authors
  1. María Paz Guerrero-Molina
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  2. Jesús González de la Aleja
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Contributions

María Paz Guerrero-Molina is the main author and has taken part in the conceptualization, study design, data collection, statistical analysis, investigation about the problem, writing the original draft, and validation of results and the final manuscript. Jesús González de la Aleja has led the conceptualization, supervision, and manuscript review and final editing. He has made an essential contribution to the investigation, methodology, project administration, validation of our results, and the final version.

Corresponding author

Correspondence to María Paz Guerrero-Molina.

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Conflict of interest

The authors declare no competing interests.

Ethical approval

This study received approval from the Ethics Committee of the University Hospital 12 de Octubre (Madrid, Spain; approval number: 20/032).

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All subjects provided written informed consent.

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Guerrero-Molina, M.P., González de la Aleja, J. Reply: assessing the effect of oral glutamine on the MELAS phenotype requires appropriate study designs. Neuroradiology 66, 461–462 (2024). https://doi.org/10.1007/s00234-024-03299-x

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  • DOI: https://doi.org/10.1007/s00234-024-03299-x

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