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Altered thalamic volume in patients with mild autonomous cortisol secretion: a structural brain MRI study

  • Advanced Neuroimaging
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Abstract

Purpose

To compare thalamic volume and cognitive functions of patients with mild autonomous cortisol secretion (MACS) with control subjects and patients with overt Cushing’s syndrome (CS).

Methods

In this cross-sectional study, volumes of regions of interest were assessed using 3 T magnetic resonance imaging and a voxel-based morphometry approach in 23 patients with MACS, 21 patients with active CS, 27 patients with CS in remission, and 21 control subjects. Cognitive functions were assessed using validated questionnaires.

Results

Patients with MACS had smaller left thalamic (F = 3.8, p = 0.023), left posterior thalamic (F = 4.9, p = 0.01), left medial thalamic (F = 4.7, p = 0.028), and right lateral thalamic (F = 4.1, p = 0.025) volumes than control subjects. Patients with active CS also had smaller left thalamic (F = 3.8, p = 0.044), left posterior thalamic (F = 4.9, p = 0.007), left medial thalamic (F = 4.7, p = 0.006), and right lateral thalamic (F = 4.1, p = 0.042) volumes compared to controls. Patients with CS in remission had smaller left medial (F = 4.7, p = 0.030) and right lateral thalamic (F = 4.1, p = 0.028) volumes than controls. Neuropsychological tests showed no difference between the groups.

Conclusion

MACS may decrease thalamic volume.

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Funding

This study was funded by The Scientific and Technological Research Council of Turkiye (Project No: 220S794).

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Authors and Affiliations

  1. Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Türkiye

    Cem Sulu, Serdar Sahin, Pinar Kadioglu & Hande Mefkure Ozkaya

  2. Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Türkiye

    Oguzhan Koca & Tevhide Betul Icli

  3. Department of Radiology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Türkiye

    Ahmet Oz, Osman Aykan Kargin & Serdar Arslan

  4. Bagcilar State Hospital, Istanbul, Türkiye

    Emre Durcan

  5. Department of Psychiatry, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Türkiye

    Senol Turan

  6. Pituitary Center, Istanbul University-Cerrahpasa, Istanbul, Türkiye

    Pinar Kadioglu & Hande Mefkure Ozkaya

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  1. Cem Sulu
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Correspondence to Hande Mefkure Ozkaya.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The present study was approved by the Medical Research Ethics Committee of Cerrahpasa Medical Faculty (03.05.2021/45781).

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Sulu, C., Koca, O., Icli, T.B. et al. Altered thalamic volume in patients with mild autonomous cortisol secretion: a structural brain MRI study. Neuroradiology 65, 1037–1051 (2023). https://doi.org/10.1007/s00234-023-03156-3

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