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Altered time-varying local spontaneous brain activity pattern in patients with high myopia: a dynamic amplitude of low-frequency fluctuations study

  • Functional Neuroradiology
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Abstract

Purpose

To investigate the abnormal time-varying local spontaneous brain activity in patients with high myopia (HM) on the basis of the dynamic amplitude of low-frequency fluctuations (dALFF) approach.

Methods

Age and gender matching were performed based on resting-state functional magnetic resonance imaging data from 86 HM patients and 87 healthy controls (HCs). Local spontaneous brain activities were evaluated using the time-varying dALFF method. Support vector machine combined with the radial basis function kernel was used for pattern classification analysis.

Results

Inter-group comparison between HCs and HM patients has demonstrated that dALFF variability in the left inferior frontal gyrus (orbital part), left lingual gyrus, right anterior cingulate and paracingulate gyri, and right calcarine fissure and surrounding cortex was decreased in HM patients, while increased in the left thalamus, left paracentral lobule, and left inferior parietal (except supramarginal and angular gyri). Pattern classification between HM patients and HCs displayed a classification accuracy of 85.5%.

Conclusion

In this study, the findings mentioned above have suggested the association between local brain activities of HM patients and abnormal variability in brain regions performing visual sensorimotor and attentional control functions. Several useful information has been provided to elucidate the mechanism-related alterations of the myopic nervous system. In addition, the significant role of abnormal dALFF variability has been highlighted to achieve an in-depth comprehension of the pathological alterations and neuroimaging mechanisms in the field of HM.

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Funding

This work was supported by The First Affiliated Hospital of Zhengzhou University (Grant No: YNQN2017160) and Henan Province Key R&D and Promotion Project (Science and Technology Research) (Grant No: 222102310317).

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  1. Xiaopan Zhang and Liang Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

    Xiaopan Zhang, Liang Liu, Shaoqiang Han, Yinhuan Xu, Bingqian Zhou, Jingli Chen, Yong Zhang, Baohong Wen & Jingliang Cheng

  2. Henan Key Laboratory of Magnetic Resonance and Brain Function, Zhengzhou, 450052, China

    Xiaopan Zhang & Shaoqiang Han

  3. Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

    Xuemin Jin & Fan Yang

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Zhang, X., Liu, L., Jin, X. et al. Altered time-varying local spontaneous brain activity pattern in patients with high myopia: a dynamic amplitude of low-frequency fluctuations study. Neuroradiology 65, 157–166 (2023). https://doi.org/10.1007/s00234-022-03033-5

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