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Vertebral augmentation with spinal implants: third-generation vertebroplasty


This article is to review the different types of vertebral augmentation implants recently becoming available for the treatment of benign and malignant spinal compression fractures. After a detailed description of the augmentation implants, we review the available clinical data. We will conclude with a summary of the advantages and disadvantages of vertebral implants and how they can affect the future treatment options of compression fractures.

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Balloon kyphoplasty


Vertebral body




Visual analog score


Ostwestery disability score


Vertebral body stent


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Correspondence to Bassem A. Georgy.

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Conflict of interest

Medtronic, Spineology, Merit Medical, Johnson & Johnson, SpinTech, Imaging3, IZI, Medlantis, Techlamed, Consultant, Peterson Enterprises, Medical Metrics, Radius Pharmaceuticals, Avanos, Vertiflex, Sollis Pharmaceuticals, Simplify Medical, Stryker, Lenoss Medical, Spine BioPharma, Piramal, ReGelTec, Nanofuse, Talosix, Spinal Simplicity, Pain Theory, Spark Biomedical. Medtronic, SpinTech, Medical Metrics, Avanos, Relievant, Vertiflex, Stryker, Sollis Pharmaceuticals, Simplify Medical, Lenoss Medical, Spine BioPharma. Medtronic, Imaging3, ReGelTec, Nanofuse, Talosix, Spinal Simplicity, Pain Theory, Spark Biomedical. SpinTech, Nocimed. Artio, Sophiris, Eleven Biotherapeutics, Radius Pharmaceuticals, Flow Forward, Lenoss Medical, Spine BioPharma. Thieme, Springer, Humana. Radius Pharmaceuticals, Stryker, Medtronic, Vertiflex, Merit, Medlantis, Avanos, Piramal.

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All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards

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Informed consent was obtained from all individual participants included in the study.

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Key Points

1. Describe different types of vertebral implants available for treatment of spinal compression fractures

2. Outline published clinical data for each implant

3. Summarize the pros and cons of this new technique, the so called third generation vertebroplasty

4. Outline future role in treatment of traumatic and malignant lesions

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Manz, D., Georgy, M., Beall, D.P. et al. Vertebral augmentation with spinal implants: third-generation vertebroplasty. Neuroradiology 62, 1607–1615 (2020).

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  • Vertebroplasty
  • Kyphoplasty
  • Compression fractures
  • Implants