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Cerebral amyloid angiopathy with focal presentation—about 3 cases

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Abstract

Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease involved in ischemic and hemorrhagic strokes, and its progression is correlated to cognitive decline. In vivo diagnosis of CAA is guided by the modified Boston criteria, with the presence of multiple intracerebral hemorrhage or cerebral microbleeds (CMB), or single hemorrhage and cortical superficial siderosis. The diagnosis of CAA is highly dependent on the quality of imaging and the advent of susceptibility-weighted imaging (SWI) sequences has improved sensitivity of MRI to detect hemosiderin deposition and CMB, hallmarks of CAA. We report here 3 clinical cases of patients with Alzheimer’s disease and a focal form (i.e., not disseminated) of probable CAA, diagnosed with SWI sequences. Focal CAA may require closer attention and could offer keys in the understanding of both Alzheimer’s disease and CAA pathogenesis.

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Anonymized data will be available from the corresponding author upon reasonable request.

References

  1. Yamada M (2015) Cerebral amyloid angiopathy: emerging concepts. J Stroke 17:17–30. https://doi.org/10.5853/jos.2015.17.1.17

    Article  PubMed  PubMed Central  Google Scholar 

  2. Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM (2017) Emerging concepts in sporadic cerebral amyloid angiopathy. Brain 140:1829–1850. https://doi.org/10.1093/brain/awx047

    Article  PubMed  PubMed Central  Google Scholar 

  3. Greenberg SM, Charidimou A (2018) Diagnosis of cerebral amyloid angiopathy: evolution of the Boston criteria. Stroke 49:491–497. https://doi.org/10.1161/STROKEAHA.117.016990

    Article  PubMed  PubMed Central  Google Scholar 

  4. Shams S, Martola J, Cavallin L, Granberg T, Shams M, Aspelin P, Wahlund LO, Kristoffersen-Wiberg M (2015) SWI or T2*: which MRI sequence to use in the detection of cerebral microbleeds? The Karolinska Imaging Dementia Study. Am J Neuroradiol 36:1089–1095. https://doi.org/10.3174/ajnr.A4248

    Article  CAS  PubMed  Google Scholar 

  5. Jack CR, Bennett DA, Blennow K et al (2018) NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement 14:535–562. https://doi.org/10.1016/j.jalz.2018.02.018

    Article  PubMed  PubMed Central  Google Scholar 

  6. Pasquier F, Leys D, Weerts JG et al (1996) Inter- and intraobserver reproducibility of cerebral atrophy assessment on MRI scans with hemispheric infarcts. Eur Neurol 36:268–272. https://doi.org/10.1159/000117270

    Article  CAS  PubMed  Google Scholar 

  7. Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J (1992) Atrophy of medial temporal lobes on MRI in “probable” Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 55:967–972. https://doi.org/10.1136/jnnp.55.10.967

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Fotiadis P, van Rooden S, van der Grond J, Schultz A, Martinez-Ramirez S, Auriel E, Reijmer Y, van Opstal AM, Ayres A, Schwab KM, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Hedden T, Rosand J, Viswanathan A, Wermer M, Terwindt GM, Sperling RA, Polimeni JR, Johnson KA, van Buchem MA, Greenberg SM, Gurol ME (2016) Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study. Lancet Neurol 15:811–819. https://doi.org/10.1016/S1474-4422(16)30030-8

    Article  PubMed  PubMed Central  Google Scholar 

  9. Ronsin S, Deiana G, Geraldo AF, Durand-Dubief F, Thomas-Maisonneuve L, Formaglio M, Desestret V, Meyronet D, Nighoghossian N, Berthezène Y, Honnorat J, Ducray F (2016) Pseudotumoral presentation of cerebral amyloid angiopathy–related inflammation. Neurology 86:912–919. https://doi.org/10.1212/WNL.0000000000002444

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Karageorgiou E, Naasan G, Pleasure SJ, Alexandrescu S, Gelfand JM, Tammewar G, Miller BL, Rabinovici GD, Grinberg LT (2017) Focal cerebral β-amyloid angiopathy: a distinct clinicopathologic presentation. Neurol Clin Pract 7:444–448. https://doi.org/10.1212/CPJ.0000000000000354

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

The authors have not declared a specific grant for this research from any funding agency in the public, commercial, or not-for-profit sectors.

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Author notes

  1. AG-C and AT contributed equally to the manuscript.

Authors and Affiliations

  1. Institut du Vieillissement I-Vie, Hospices Civils de Lyon, 27 rue Gabriel Péri, 69100, Villeurbanne, France

    Antoine Garnier-Crussard, Amélie Taki, Marc Bonnefoy, Jean-Yves Bar, Pierre Krolak-Salmon & Thomas Gilbert

  2. Centre Mémoire Ressource et Recherche de Lyon (CMRR), Hospices Civils de Lyon, Lyon, France

    Antoine Garnier-Crussard, Amélie Taki, Marc Bonnefoy, Jean-Yves Bar, Pierre Krolak-Salmon & Thomas Gilbert

  3. CREATIS – CNRS, UMR 5220; INSERM, U1044, Claude Bernard University Lyon 1, Lyon, France

    François Cotton

  4. Service de Radiologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pierre-Bénite, France

    François Cotton

Authors
  1. Antoine Garnier-Crussard
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  2. Amélie Taki
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  3. Marc Bonnefoy
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  4. Jean-Yves Bar
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  5. Pierre Krolak-Salmon
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  6. François Cotton
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  7. Thomas Gilbert
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Correspondence to Antoine Garnier-Crussard.

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Garnier-Crussard, A., Taki, A., Bonnefoy, M. et al. Cerebral amyloid angiopathy with focal presentation—about 3 cases. Neuroradiology 62, 1195–1197 (2020). https://doi.org/10.1007/s00234-020-02450-8

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  • DOI: https://doi.org/10.1007/s00234-020-02450-8

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