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European multicentre study on technical success and long-term clinical outcome of radiofrequency ablation for the treatment of spinal osteoid osteomas and osteoblastomas

  • Interventional Neuroradiology
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A Correction to this article was published on 19 June 2019

This article has been updated

Abstract

Purpose

To evaluate technical success and long-term outcome of CT-guided radiofrequency ablation (RFA) of spinal osteoid osteomas (OO) and osteoblastomas (OB) in six different European centres.

Methods

Eighty-seven patients with spinal OO (77) or OB (10) were treated with CT-guided RFA, after three-dimensional CT-guided access planning. Patient’s long-term outcome was assessed by clinical examination and questionnaire-based evaluation including 10-point visual analogue scales (VAS) regarding the effect of RFA on severity of pain and limitations of daily activities. Clinical success was defined as a reduction of > 30% in the VAS score and patient’s satisfaction.

Results

Overall, RFA was technically successful in 82/87 cases (94.3%) with no major complications; clinical success was achieved in 78/87 cases (89.7%). The OO/OB were localized in the cervical (n = 9/3), the thoracic (n = 27/1), the lumbar (n = 29/4), and the sacral spine (n = 12/2). A decrease in severity of pain after RFA was observed in 86/87 patients (98.9%) with a persistent mean reduction of overall pain score from 8.04 ± 0.96 to 1.46 ± 1.95 (p < 0.001) after a median follow-up time of 29.35 ± 35.59 months. VAS scores significantly decreased for limitations of both daily (5.70 ± 2.73 to 0.67 ± 1.61, p < 0.001) and sports activities (6.40 ± 2.58 to 0.67 ± 1.61, p < 0.001).

Conclusion

In a multicentric setting, this trial proves RFA to be a safe and efficient method to treat spinal OO/OB and should be regarded as first-line therapy after interdisciplinary case discussion.

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Change history

  • 19 June 2019

    The original version of this paper contained an error: the Acknowledgements were dropped during early manuscript editing.

Notes

  1. Of all the biopsies performed, 15 were consistent with the radiological diagnosis of osteoid osteoma. In three cases, a biopsy attempt was made but no material could be obtained. All other biopsies, performed at the Leiden centre, supplied insufficient material for classifying diagnosis.

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Funding

This study received no funding.

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Authors and Affiliations

  1. Institute of Diagnostic and Interventional Radiology, Paediatric Radiology and Neuroradiology, University Medical Centre Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany

    Thomas Beyer, Kolja M. Thierfelder & Marc-André Weber

  2. Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands

    Carla S. P. van Rijswijk

  3. Diagnóstico por Imagen, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain

    Jose Martel Villagrán

  4. Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany

    Christoph Rehnitz & Marc-André Weber

  5. Neuroradiology Department, Cardarelli Hospital, Naples, Italy

    Mario Muto

  6. Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany

    Christian von Falck

  7. Department of Radiology, Antwerp University Hospital, Antwerp, Belgium

    Jan Gielen

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  1. Thomas Beyer
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Correspondence to Thomas Beyer.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Beyer, T., van Rijswijk, C.S.P., Villagrán, J.M. et al. European multicentre study on technical success and long-term clinical outcome of radiofrequency ablation for the treatment of spinal osteoid osteomas and osteoblastomas. Neuroradiology 61, 935–942 (2019). https://doi.org/10.1007/s00234-019-02226-9

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  • DOI: https://doi.org/10.1007/s00234-019-02226-9

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