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Correlation of post-contrast T1-weighted MRI surface regularity, tumor bulk, and necrotic volume with Ki67 and p53 in glioblastomas

  • Diagnostic Neuroradiology
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Abstract

Purpose

p53 and Ki67 status can be relevant to the management of glioblastoma. The goal of this study is to determine whether tumor morphology and bulk depicted on MRI correlate with p53 and Ki67 in glioblastoma.

Methods

A retrospective review of 223 patients with glioblastoma and corresponding p53 or Ki67 status, along with T1-weighted post-contrast MR images was performed. Enhancing tumors were outlined for determining surface regularity, tumor bulk, and necrotic volume. The median value of 0.1 was chosen for p53 and 0.2 for Ki67 to separate each data set into two classes. T tests and receiver operating characteristic analysis were performed to determine the separation of the classes and the predicting power of each feature.

Results

There were significant differences between tumor surface regularity (p = 0.01) and necrotic volume (p = 0.0429) according to Ki67 levels, although neither had statistically significant predictive power (AUC = 0.697, p = 0.0506 and AUC = 0.577, p = 0.164, respectively). There were also significant differences between tumor bulk (p = 0.0239) and necrotic volume (p = 0.0200) according to p53 levels, but again no significant predictive power was found using ROC analysis (AUC = 0.5882, p = 0.0894 and AUC = 0.567, p = 0.155, respectively).

Conclusion

Quantitative morphological tumor characteristics on post-contrast T1-weighted MRI can to a certain degree provide insights regarding Ki67 and p53 status in patients with glioblastoma.

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Authors and Affiliations

  1. Graduate Program in Medical Physics, University of Chicago, Chicago, IL, USA

    Adam Hasse

  2. Pritzker School of Medicine, University of Chicago, Chicago, IL, USA

    Mark Dapash

  3. Department of Biomedical Engineering, Northwestern University, Chicago, IL, USA

    Yong Jeong

  4. Department of Radiology, Northwestern University, Chicago, IL, USA

    Sameer A. Ansari

  5. Department of Radiology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA

    Timothy J. Carroll & Daniel Thomas Ginat

  6. Department of Neurosurgery, Northwestern University, Chicago, IL, USA

    Maciej Lesniak

Authors
  1. Adam Hasse
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  2. Mark Dapash
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  3. Yong Jeong
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  4. Sameer A. Ansari
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  5. Timothy J. Carroll
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  6. Maciej Lesniak
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  7. Daniel Thomas Ginat
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Correspondence to Daniel Thomas Ginat.

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Funding

This work is supported, in part, by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Grant no. T32 EB002103.

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The authors declare that they have no conflict of interest.

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Hasse, A., Dapash, M., Jeong, Y. et al. Correlation of post-contrast T1-weighted MRI surface regularity, tumor bulk, and necrotic volume with Ki67 and p53 in glioblastomas. Neuroradiology 61, 861–867 (2019). https://doi.org/10.1007/s00234-019-02204-1

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  • DOI: https://doi.org/10.1007/s00234-019-02204-1

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