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Gray matter reduction related to decreased serum creatinine and increased triglyceride, Hemoglobin A1C, and low-density lipoprotein in subjects with obesity

  • Functional Neuroradiology
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Abstract

Purpose

Altered brain volume and metabolic variables have been found in subjects with obesity. However, the role of metabolic parameters in gray matter volume (GMV) has been poorly investigated. This study aimed to investigate the relationship between the metabolic parameters and brain volume in subjects with obesity.

Methods

Thirty-seven subjects with obesity and 39 age and sex matched normal-weight controls were included in this study. Eighteen of the 37 participants who underwent sleeve gastrectomy were included in the longitudinal analysis. Blood samples and high-resolution 3T T1-weighted magnetic resonance images were collected. Metabolic parameters in plasma and GMV were measured.

Results

Multiple linear regression analysis showed that gray matter reduction in several cognition-related cortices including right angular gyrus, superior occipital cortex, superior parietal cortex, and cerebellum was related to decreased creatinine, as well as increased triglyceride, HbA1c, and low-density lipoprotein in plasma in subjects with obesity. Weight loss after the surgery induced significant recovery of altered metabolic parameters and decreased gray matter volume. Furthermore, changes in the four metabolic parameters before and after the surgery were associated with changes in gray matter volume.

Conclusion

Our results suggest that the gray matter reduction is related to decreased creatinine as well as increased triglyceride, HbA1c, and low-density lipoprotein in plasma in subjects with obesity.

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Acknowledgements

The authors thank the patients and healthy volunteers who took part in this study.

Funding

This study was funded by the National Natural Science Foundation of China (Grant nos. 8177192, 81671770).

Author information

Author notes

  1. HS and PL contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Chinese People’s Liberation Army General Hospital, Beijing, 100853, China

    Han Shan & Lin Ma

  2. Department of Physics, Zhengzhou University, Zhengzhou, 450001, Henan, China

    Panlong Li, Xiaolong Yin, Xi Sun, Ting Feng, Luying Wang, Yichao Hu & Demin Li

  3. Beijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China

    Panlong Li, Hua Liu, Binbin Nie, Xiaolong Yin, Tianhao Zhang, Xi Sun, Wei Zhang, Ting Feng, Luying Wang & Baoci Shan

  4. Department of General Surgery, Chinese People’s Liberation Army General Hospital, Beijing, China

    Guanglong Dong

  5. Department of General Surgery, The General Hospital of Chinese People’s Armed Police Forces, Beijing, 100039, China

    Hongkai Gao

  6. Department of Endocrinology, Chinese People’s Liberation Army General Hospital, Beijing, China

    Jin Du

  7. School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing, 100049, China

    Baoci Shan

Authors
  1. Han Shan
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  2. Panlong Li
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  3. Hua Liu
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Corresponding author

Correspondence to Baoci Shan.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Cite this article

Shan, H., Li, P., Liu, H. et al. Gray matter reduction related to decreased serum creatinine and increased triglyceride, Hemoglobin A1C, and low-density lipoprotein in subjects with obesity. Neuroradiology 61, 703–710 (2019). https://doi.org/10.1007/s00234-019-02202-3

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  • DOI: https://doi.org/10.1007/s00234-019-02202-3

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