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Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors

  • Diagnostic Neuroradiology
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Abstract

Purpose

To explore the utility of the apparent diffusion coefficient (ADC) and tumor volume to predict histological grade and prognosis in patients with choroid plexus tumors.

Methods

ADC and tumor volumes were retrospectively evaluated in 25 patients with choroid plexus papilloma (CPP; WHO grade 1 [n = 13]), atypical CPP (aCPP; grade 2 [n = 8]), or choroid plexus carcinoma (grade 3 [n = 4]) The prognostic roles of ADC and tumor volume were assessed.

Results

There were significant differences in mean and minimum ADC values, and tumor volume among the WHO grades (p = 0.033, p = 0.044, and p = 0.014, respectively). Receiver-operating characteristic analysis revealed a mean cutoff ADC value ≤ 1.397 × 10−3 mm2/s for aCPP (sensitivity = 0.667, specificity = 0.923). Multiple linear regression analysis demonstrated that both mean ADC (β = − 0.455, p = 0.005) and tumor volume (β = 0.513, p = 0.002) were correlated with WHO grade (adjusted R2 = 0.520, p = 0.005). Kaplan-Meier curve analysis identified poorer survival in patients with WHO grade 2 and 3 tumors than in those with WHO grade 1 disease (p = 0.049 and p = 0.012, respectively). A mean ADC ≤ 1.397 × 10−3 mm2/s (p = 0.001) and tumor volume 21.05 ml (p = 0.031) predicted significantly poorer survival.

Conclusion

Mean ADC and tumor volume were correlated with WHO grade of choroid plexus tumors. A lower ADC value and a larger tumor volume predicted a poorer prognosis.

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Authors and Affiliations

  1. Department of Radiology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Tomoaki Sasaki, Toshio Moritani, Aristides A. Capizzano, Shawn P. Sato & Yutaka Sato

  2. Department of Radiology, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan

    Tomoaki Sasaki, Shunta Ishitoya, Akiko Oya, Masahiro Toda & Koji Takahashi

  3. Department of Radiology, University of Michigan, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109, USA

    John Kim & Toshio Moritani

  4. Department of Pathology, University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA

    Patricia Kirby

  5. Department of Diagnostic Pathology, Asahikawa Medical University Hospital, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido, 078-8510, Japan

    Sayaka Yuzawa

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  1. Tomoaki Sasaki
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Correspondence to Tomoaki Sasaki.

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Funding

TS was funded by JSPS KAKENHI Grant Number JP15K19762.

Conflict of interest

The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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For this type of retrospective study formal consent is not required.

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Sasaki, T., Kim, J., Moritani, T. et al. Roles of the apparent diffusion coefficient and tumor volume in predicting tumor grade in patients with choroid plexus tumors. Neuroradiology 60, 479–486 (2018). https://doi.org/10.1007/s00234-018-2008-2

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  • DOI: https://doi.org/10.1007/s00234-018-2008-2

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