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Quantitative multiparametric MRI in uveal melanoma: increased tumor permeability may predict monosomy 3

  • Head and Neck Radiology
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Neuroradiology Aims and scope Submit manuscript

Abstract

Introduction

Uveal melanoma is a rare intraocular tumor with heterogeneous biological behavior, and additional noninvasive markers that may predict outcome are needed. Diffusion- and perfusion-weighted imaging may prove useful but have previously been limited in their ability to evaluate ocular tumors. Our purpose was to show the feasibility and potential value of a multiparametric (mp-) MRI protocol employing state of the art diffusion- and perfusion-weighted imaging techniques.

Methods

Sixteen patients with uveal melanoma were imaged with mp-MRI. Multishot readout-segmented echoplanar diffusion-weighted imaging, quantitative dynamic contrast-enhanced (DCE) MR perfusion imaging, and anatomic sequences were obtained. Regions of interest (ROIs) were drawn around tumors for calculation of apparent diffusion coefficient (ADC) and perfusion metrics (K trans, v e , k ep , and v p ). A generalized linear fit model was used to compare various MRI values with the American Joint Commission on Cancer (AJCC) tumor group and monosomy 3 status with significance set at P < 0.05.

Results

mp-MRI was performed successfully in all cases. MRI tumor height (mean [standard deviation]) was 6.5 mm (3.0). ROI volume was 278 mm3 (222). ADC was 1.07 (0.27) × 10–3 mm2/s. DCE metrics were K trans 0.085/min (0.063), v e 0.060 (0.052), k ep 1.20/min (0.32), and v p 1.48 % (0.82). Patients with >33 % monosomy 3 had higher K trans and higher v e values than those with disomy 3 or ≤33 % monosomy (P < 0.01). There were no significant differences between ADC (P = 0.07), k ep (P = 0.37), and v p with respect to monosomy 3.

Conclusion

mp-MRI for ocular tumor imaging using multishot EPI DWI and quantitative DCE perfusion is technically feasible. mp-MRI may help predict monosomy 3 in uveal melanoma.

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Abbreviations

DWI:

Diffusion-weighted imaging

DCE:

Dynamic contrast-enhanced

ADC:

Apparent diffusion coefficient

CISS:

Constructive interference in steady state

EPI:

Echoplanar imaging

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Ethical standards and patient consent

We declare that all human and animal studies have been approved by the UCLA Institutional Review Board and the UCLA Jonsson Comprehensive Cancer Center, and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Patient consent was waived for the use of patient records in this research study.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of California Los Angeles, 200 Medical Plaza, Ste B265, Los Angeles, CA, 90095, USA

    Mitchell Kamrava, Pin-Chieh Wang, Kristofer Roberts & D. Jeffrey Demanes

  2. Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA

    Ali R Sepahdari, Kevin Leu & Benjamin M. Ellingson

  3. Department of Ophthalmology, University of California Los Angeles, Los Angeles, CA, USA

    Tara McCannel

Authors
  1. Mitchell Kamrava
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  2. Ali R Sepahdari
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  3. Kevin Leu
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  4. Pin-Chieh Wang
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  5. Kristofer Roberts
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  6. D. Jeffrey Demanes
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  7. Tara McCannel
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  8. Benjamin M. Ellingson
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Corresponding author

Correspondence to Ali R Sepahdari.

Additional information

Mitchell Kamrava and Ali R Sepahdari contributed equally to this work.

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Kamrava, M., Sepahdari, A.R., Leu, K. et al. Quantitative multiparametric MRI in uveal melanoma: increased tumor permeability may predict monosomy 3. Neuroradiology 57, 833–840 (2015). https://doi.org/10.1007/s00234-015-1546-0

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  • DOI: https://doi.org/10.1007/s00234-015-1546-0

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