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High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma

Part 1: MRI vs. histopathology

Neuroradiology volume 57, pages 805–814 (2015)Cite this article

Abstract

Introduction

A reliable detection of metastatic risk factors is important for children with retinoblastoma to choose the right therapeutic regimen. First studies using high-resolution magnetic resonance imaging (MRI) with orbit surface coils were promising. The aim of this study was therefore to evaluate the ability of high-resolution MRI to detect metastatic and especially advanced metastatic risk factors in a large group of children with retinoblastoma.

Methods

One hundred forty-three consecutive children with retinoblastoma (148 enucleated eyes, 64 girls, 79 boys, mean age 19.7 ± 15.3) who received pretherapeutical high-resolution MRI with orbit surface coils on 1.5 T MR scanner systems between 2007 and 2012 and subsequent primary enucleation within 14 days were included in this retrospective study. Image analysis was performed by two neuroradiologists experienced in ocular imaging in consensus. Histopathology served as gold standard.

Results

Sensitivity/specificity for the detection of metastatic risk factors using high-resolution MRI with orbit surface coils were 60 %/88.7 % for postlaminar optic nerve infiltration, 65.5 %/95.6 % for choroidal invasion, 100 %/99.3 % for scleral invasion, and 100 %/100 % for peribulbar fat invasion, respectively. The results increased for the detection of advanced metastatic risk factors, 81.8 %/89.1 % for deep postlaminar optic nerve infiltration, 70.6 %/97.6 % for massive choroidal invasion.

Conclusions

High-resolution MRI is clinically valuable for the detection of metastatic, especially of advanced metastatic risk factors in children with retinoblastoma.

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Ethical standards and patient consent

We declare that all human and animal studies have been approved by the Ethics Committee of the University of Duisburg-Essen and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.

Author information

Affiliations

  1. Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany

    Selma Sirin, Marc Schlamann, Bernd Schweiger & Sophia L. Goericke

  2. Department of Pathology and Neuropathology, University Hospital Essen, Essen, Germany

    Klaus A. Metz

  3. Department of Ophthalmology, University Hospital Essen, Essen, Germany

    Norbert Bornfeld & Markus Holdt

  4. Department of Pediatric Hematology and Oncology, University Hospital Essen, Essen, Germany

    Petra Temming & Michael M. Schuendeln

Authors
  1. Selma Sirin
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  2. Marc Schlamann
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  9. Sophia L. Goericke
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Correspondence to Selma Sirin.

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Sirin, S., Schlamann, M., Metz, K.A. et al. High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma. Neuroradiology 57, 805–814 (2015). https://doi.org/10.1007/s00234-015-1544-2

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  • DOI: https://doi.org/10.1007/s00234-015-1544-2

Keywords

  • MRI
  • Retinoblastoma
  • Tumor extension
  • Histology
  • Eye