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Nationwide survey of the nature and risk factors of complications in embolization of meningiomas and other intracranial tumors: Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2)

  • Interventional Neuroradiology
  • Published:
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Abstract

Introduction

Embolization of intracranial tumor is widely performed in Japan, mainly before neurosurgical resection. A retrospective, multicenter, observational study in Japan was conducted to clarify the nature, frequency, and risk factors of complications in intracranial tumor embolization.

Methods

Patients were derived from the Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2). A total of 20,854 patients were enrolled in JR-NET2, of which 1,018 patients (4.88 %) with intracranial tumors underwent embolization. The primary end point was the proportion of patients with a modified Rankin scale (mRS) score of 0–2 (independency) at 30 days. The secondary end point was the occurrence of complications related to the procedures. The risk factors of the occurrence of complications were studied.

Results

The proportion of patients with mRS scores ≤2 at 30 days after procedure was 91.3 %. Complications occurred in 15 of the 1,012 patients (1.48 %). Multivariate analysis showed that embolization for tumors other than meningioma (OR, 4.626; 95 % CI, 1.347–14.59; p = 0.0105) was significantly associated with the development of complications.

Conclusion

The frequency of complications after intracranial tumor embolization was relatively low in this large Japanese cohort. Embolization for tumors other than meningioma was the only significant risk factor for the occurrence of complications.

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Abbreviations

ECA:

External carotid artery

ICA:

Internal carotid artery

IQR:

Interquartile range

JR-NET:

Japanese Registry of NeuroEndovascular Therapy

mRS:

Modified Rankin scale

VBA:

Vertebrobasilar artery

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Acknowledgments

This study was supported by research grants for cardiovascular diseases (17C-1, 20C-2) from the Ministry of Health, Labor, and Welfare of Japan. The authors would like to express heartfelt thanks to doctors who devoted their time to this investigation. The JR-NET Study Group: principal investigator Nobuyuki Sakai, Kobe City Medical Center General Hospital, Kobe, Japan; investigators Akio Hyodo, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Japan (17C-1, 20C-2); Shigeru Miyachi, Nagoya University, Nagoya, Japan (17C-1, 20C-2); Yoji Nagai, Translational Research Informatics Center, Kobe, Japan (17C-1, 20C-2); Chiaki Sakai, Institute of Biomedical Research and Innovation, Kobe, Japan (17C-1, 20C-2); Tetsu Satoh, National Cerebral and Cardiovascular Center, Suita, Japan (17C-1, 20C-2); Waro Taki, Mie University, Tsu, Japan (17C-1, 20C-2); Tomoaki Terada, Wakayama Rosai Hospital, Wakayama, Japan (17C-1, 20C-2); Masayuki Ezura, Sendai Medical Center, Sendai, Japan (17C-1); Toshio Hyogo, Nakamura Memorial Hospital, Sapporo, Japan (17C-1); Shunji Matsubara, Tokushima University, Tokushima, Japan (17C-1); Kentaro Hayashi, Nagasaki University, Nagasaki Japan (20C-2); co-investigators Toshiyuki Fujinaka, Osaka University, Suita, Japan; Yasushi Ito, Niigata University, Niigata, Japan; Shigeki Kobayashi, Chiba Emergency Medical Center, Chiba, Japan; Masaki Komiyama, Osaka City General Hospital, Osaka, Japan; Naoya Kuwayama, Toyama University, Toyama, Japan; Yuji Matsumaru, Toranomon Hospital, Japan; Yasushi Matsumoto, Konan Hospital, Sendai, Japan; Yuichi Murayama, Jikei Medical University, Tokyo, Japan; Ichiro Nokahara, Kokura Memorial Hospital, Kokura, Japan; Shigeru Nemoto, Jichi Medical University, Shimotsuke, Japan; Koichi Sato, Tokushima Red Cross Hospital, Tokushima, Japan; Kenji Sugiu, Okayama University, Okayama, Japan; Shinichi Yoshimura, Gifu University, Gifu, Japan; and the certified specialist of Japanese Society of Neuroendovascular Therapy.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama, 700-8558, Japan

    Tomohito Hishikawa, Kenji Sugiu, Masafumi Hiramatsu, Jun Haruma, Koji Tokunaga & Isao Date

  2. Department of Neurosurgery, Kobe City Medical Center General Hospital, Kobe, Japan

    Nobuyuki Sakai

Authors
  1. Tomohito Hishikawa
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  2. Kenji Sugiu
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  3. Masafumi Hiramatsu
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  4. Jun Haruma
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  5. Koji Tokunaga
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  6. Isao Date
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  7. Nobuyuki Sakai
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Corresponding author

Correspondence to Tomohito Hishikawa.

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Hishikawa, T., Sugiu, K., Hiramatsu, M. et al. Nationwide survey of the nature and risk factors of complications in embolization of meningiomas and other intracranial tumors: Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2). Neuroradiology 56, 139–144 (2014). https://doi.org/10.1007/s00234-013-1300-4

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  • DOI: https://doi.org/10.1007/s00234-013-1300-4

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