Abstract
Introduction
Preoperative embolization of a carotid body tumor (CBT) is a useful adjunct prior to surgical excision because it decreases operative blood loss and improves surgical outcomes. Traditionally, this is performed by transarterial particulate embolization (TAPE). More recently, direct percutaneous embolization (DPE) with Onyx is recognized as a promising technique for preoperative embolization. We compared these two techniques in patients treated for CBTs at our institution.
Methods
We retrospectively reviewed cases of preoperative devascularization of CBT from 1 January 1995 through 1 September 2012. Patient cases were placed into two groups: TAPE and DPE. Operative blood loss, operative length, angiographic devascularization, embolization procedure complications, operative transfusion requirements, postoperative hospital stay, intensive care unit (ICU) stay, and procedure-related mortalities were compared.
Results
A total of 17 patients underwent preoperative devascularization of their CBT with TAPE technique and ten patients using the DPE technique with Onyx. Average operative blood loss was significantly higher in the TAPE group (Mann–Whitney U test, p = 0.04). Operative time was also higher, although this difference was not significant. Two patients required intraoperative blood transfusions in the TAPE group while none required transfusions in the DPE group. There was no significant difference in ICU stay or length of hospitalization. One serious embolization procedure complication occurred in the TAPE group and none in the DPE group.
Conclusion
Operative blood loss in the DPE group was significantly less than the TAPE group. Blood transfusion requirement, operative time, and complications were less in the DPE group, although they did not reach statistical significance.
Similar content being viewed by others
References
Erickson D, Kudva YC, Ebersold MJ, Thompson GB, Grant CS, van Heerden JA et al (2001) Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab 86:5210–5216
Netterville JL, Reilly KM, Robertson D, Reiber ME, Armstrong WB, Childs P (1995) Carotid body tumors: a review of 30 patients with 46 tumors. Laryngoscope 105:115–126
Li J, Wang S, Zee C, Yang J, Chen W, Zhuang W et al (2010) Preoperative angiography and transarterial embolization in the management of carotid body tumor: a single-center, 10-year experience. Neurosurgery 67:941–948, discussion 8
Wanke I, Jackel MC, Goericke S, Panagiotopoulos V, Dietrich U, Forsting M (2009) Percutaneous embolization of carotid paragangliomas using solely Onyx. AJNR Am J Neuroradiol 30:1594–1597
Gemmete JJ, Chaudhary N, Pandey A, Gandhi D, Sullivan SE, Marentette LJ et al (2010) Usefulness of percutaneously injected ethylene-vinyl alcohol copolymer in conjunction with standard endovascular embolization techniques for preoperative devascularization of hypervascular head and neck tumors: technique, initial experience, and correlation with surgical observations. AJNR Am J Neuroradiol 31:961–966
Shah HM, Gemmete JJ, Chaudhary N, Pandey AS, Ansari SA (2012) Preliminary experience with the percutaneous embolization of paragangliomas at the carotid bifurcation using only ethylene vinyl alcohol copolymer (EVOH) Onyx. J Neurointerv Surg 4:125–129
Gemmete JJ, Chaudhary N, Pandey AS, McHugh JB, Marentette LJ (2011) Complete devascularization of a juvenile angiofibroma by direct percutaneous embolization with only ethylene vinyl alcohol copolymer (Onyx) through a single needle placement. J Neurointerv Surg 3:191–193
Persky MS, Setton A, Niimi Y, Hartman J, Frank D, Berenstein A (2002) Combined endovascular and surgical treatment of head and neck paragangliomas—a team approach. Head Neck 24:423–431
Unlu Y, Becit N, Ceviz M, Kocak H (2009) Management of carotid body tumors and familial paragangliomas: review of 30 years' experience. Ann Vasc Surg 23:616–620
Liapis CD, Evangelidakis EL, Papavassiliou VG, Kakisis JD, Gougoulakis AG, Polyzos AK et al (2000) Role of malignancy and preoperative embolization in the management of carotid body tumors. World J Surg 24:1526–1530
Pacheco-Ojeda L (2001) Malignant carotid body tumors: report of three cases. Ann Otol Rhinol Laryngol 110:36–40
Kollert M, Minovi AA, Draf W, Bockmuhl U (2006) Cervical paragangliomas—tumor control and long-term functional results after surgery. Skull Base 16:185–191
Kotelis D, Rizos T, Geisbusch P, Attigah N, Ringleb P, Hacke W et al (2009) Late outcome after surgical management of carotid body tumors from a 20-year single-center experience. Langenbecks Arch Surg 394:339–344
Papaspyrou K, Mann WJ, Amedee RG (2009) Management of head and neck paragangliomas: review of 120 patients. Head Neck 31:381–387
Patetsios P, Gable DR, Garrett WV, Lamont JP, Kuhn JA, Shutze WP et al (2002) Management of carotid body paragangliomas and review of a 30-year experience. Ann Vasc Surg 16:331–338
Tikkakoski T, Luotonen J, Leinonen S, Siniluoto T, Heikkila O, Paivansalo M et al (1997) Preoperative embolization in the management of neck paragangliomas. Laryngoscope 107:821–826
Abud DG, Mounayer C, Benndorf G, Piotin M, Spelle L, Moret J (2004) Intratumoral injection of cyanoacrylate glue in head and neck paragangliomas. AJNR Am J Neuroradiol 25:1457–1462
Gemmete JJ, Pandey AS, Chaudhary N, Potti TA (2012) Paradoxical embolus to the brain from embolization of a carotid body tumor. J Neurointerv Surg 4:e12
Chaloupka JC, Mangla S, Huddle DC, Roth TC, Mitra S, Ross DA et al (1999) Evolving experience with direct puncture therapeutic embolization for adjunctive and palliative management of head and neck hypervascular neoplasms. Laryngoscope 109:1864–1872
Ozyer U, Harman A, Yildirim E, Aytekin C, Akay TH, Boyvat F (2010) Devascularization of head and neck paragangliomas by direct percutaneous embolization. Cardiovasc Intervent Radiol 33:967–975
Elhammady MS, Wolfe SQ, Ashour R, Farhat H, Moftakhar R, Lieber BB et al (2010) Safety and efficacy of vascular tumor embolization using Onyx: is angiographic devascularization sufficient? J Neurosurg 112:1039–1045
Elhammady MS, Farhat H, Ziayee H, Aziz-Sultan MA (2009) Direct percutaneous embolization of a carotid body tumor with Onyx. J Neurosurg 110:124–127
Harman M, Etlik O, Unal O (2004) Direct percutaneous embolization of a carotid body tumor with n-butyl cyanoacrylate: an alternative method to endovascular embolization. Acta Radiol 45:646–648
Gobin YP, Murayama Y, Milanese K, Chow K, Gonzalez NR, Duckwiler GR et al (2001) Head and neck hypervascular lesions: embolization with ethylene vinyl alcohol copolymer—laboratory evaluation in swine and clinical evaluation in humans. Radiology 221:309–317
Casasco A, Houdart E, Biondi A, Jhaveri HS, Herbreteau D, Aymard A et al (1999) Major complications of percutaneous embolization of skull-base tumors. AJNR Am J Neuroradiol 20:179–181
Krishnamoorthy T, Gupta AK, Rajan JE, Thomas B (2007) Stroke from delayed embolization of polymerized glue following percutaneous direct injection of a carotid body tumor. Korean J Radiol 8:249–253
Arya S, Rao V, Juvekar S, Dcruz AK (2008) Carotid body tumors: objective criteria to predict the Shamblin group on MR imaging. AJNR Am J Neuroradiol 29:1349–1354
Acknowledgments
J.J.B., N.C., and A.S.P. received grant support from ev3, Irvine, CA, USA, and Microvention, Tustin, CA, USA, to study the mechanisms of aneurysm healing.
Conflict of interest
We declare that we have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Griauzde, J., Gemmete, J.J., Chaudhary, N. et al. A comparison of particulate and Onyx embolization in preoperative devascularization of carotid body tumors. Neuroradiology 55, 1113–1118 (2013). https://doi.org/10.1007/s00234-013-1220-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00234-013-1220-3