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The use of multi b values diffusion-weighted imaging in patients with acute stroke

Neuroradiology volume 55, pages 371–376 (2013)Cite this article

Abstract

Introduction

The purpose of this paper is to study the mechanism of apparent diffusion coefficient reduction after stroke by using multi b value diffusion-weighted imaging.

Methods

Ten healthy people and 25 patients with acute stroke were enrolled. In healthy volunteers, region of interests were put in the semioval center and in the precentral gyrus. In patients with acute stroke, region of interests were put in lesions and contralateral normal brain regions. ADCfast and ADCslow are thought of as a fast and a slow apparent diffusion coefficient, which result from the extracellular and intracellular compartments, respectively. p fast and p slow are regarded as the percentage of signal intensities deriving from water diffusion of the extracellular and intracellular compartments, separately. All data were analyzed using paired, two-tailed t tests. Statistical analyses were performed using SPSS 15.0.

Results

In patients with acute stroke, p fast in lesions (0.54 ± 0.11) is lower than that in normal regions (0.75 ± 0.09), while p slow is on the contrary. ADCfast and ADCslow values in lesions are less than those in normal areas. Compared with those in normal regions, p fast of lesions decreases by 28 %, and ADCfast and ADCslow of lesions went down by 27 and 36 %, respectively. There are statistically significant differences (P < 0.05) in ADCfast, ADCslow, and p fast between lesions and normal regions.

Conclusion

The increase in the volume of extracellular space and the decrease in ADCslow are the primary reasons that lead to the decrease in apparent diffusion coefficient of lesions after stroke.

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We declare that we have no conflict of interest.

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Affiliations

  1. The Department of Magnetic Resonance Imaging, The Second Affiliated Hospital of Nanchang University, 1, Minde Road, Donghu District, Nanchang, China, 330006

    Zhenghua Liu & Xinlan Xiao

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  1. Zhenghua Liu
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  2. Xinlan Xiao
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Correspondence to Xinlan Xiao.

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Liu, Z., Xiao, X. The use of multi b values diffusion-weighted imaging in patients with acute stroke. Neuroradiology 55, 371–376 (2013). https://doi.org/10.1007/s00234-012-1129-2

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  • DOI: https://doi.org/10.1007/s00234-012-1129-2

Keywords

  • Diffusion-weighted imaging
  • ADC
  • Magnetic resonance imaging
  • Stroke