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Bilateral pre- and postcentral gyrus volume positively correlates with T2-SNR of putamen in healthy adults

  • Functional Neuroradiology
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Abstract

Introduction

The aim of the present study was to investigate the correlation between local gray matter volume and signal-to-noise ratio on T2-weighted imaging (T2-SNR) of putamen in healthy adults using two tools: voxel-based morphometry (VBM) treating age as a confounding covariate to control for age-related gray matter volume changes and high spatial resolution T1-weighted imaging acquired with a 3.0-T magnetic resonance (3T-MR) scanner.

Methods

Contiguous sagittal T1-weighted images and axial T2-weighted images of the brain were obtained from 1,380 healthy participants. T2-SNR of putamen was defined as A/B, where A is the mean T2-weighted signal intensity (T2-SI) in the right and left sides of putamen, and B is the background noise. The software Statistical Parametric Mapping 5 was used for image segmentation. The association between T2-SNR of putamen and gray matter volume was assessed with VBM, treating age as a confounding covariate.

Results

A significant positive correlation was obtained between T2-SNR of putamen and bilateral pre- and postcentral gyrus volume.

Conclusion

To the best of our knowledge, this is the first VBM study to show an age-independent relationship between T2-SNR of putamen and bilateral pre- and postcentral gyrus volumes in healthy adults.

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Acknowledgments

This study was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network) from the Ministry of Education, Science, Sports and Culture of Japan.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Masami Goto, Kenji Ino & Keiichi Yano

  2. Department of Radiology, Nihon University School of Medicine, Tokyo, Japan

    Osamu Abe

  3. Department of Radiology, Juntendo University, Bunkyo, Japan

    Shigeki Aoki

  4. Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan

    Tosiaki Miyati

  5. Department of Radiology, University of Tokyo Hospital, Tokyo, Japan

    Hidemasa Takao, Harushi Mori, Akira Kunimatsu & Kuni Ohtomo

  6. Department of Computational Diagnostic Radiology and Preventive Medicine, University of Tokyo Hospital, Tokyo, Japan

    Naoto Hayashi

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  1. Masami Goto
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Correspondence to Masami Goto.

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Goto, M., Abe, O., Aoki, S. et al. Bilateral pre- and postcentral gyrus volume positively correlates with T2-SNR of putamen in healthy adults. Neuroradiology 55, 245–250 (2013). https://doi.org/10.1007/s00234-012-1126-5

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  • DOI: https://doi.org/10.1007/s00234-012-1126-5

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