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Comparison of 3D computer-aided with manual cerebral aneurysm measurements in different imaging modalities

  • Diagnostic Neuroradiology
  • Published:
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Abstract

Introduction

To compare intra- and inter-observer reliability of aneurysm measurements obtained by a 3D computer-aided technique with standard manual aneurysm measurements in different imaging modalities.

Methods

A total of 21 patients with 29 cerebral aneurysms were studied. All patients underwent digital subtraction angiography (DSA), contrast-enhanced (CE-MRA) and time-of-flight magnetic resonance angiography (TOF-MRA). Aneurysm neck and depth diameters were manually measured by two observers in each modality. Additionally, semi-automatic computer-aided diameter measurements were performed using 3D vessel surface models derived from CE- (CE-com) and TOF-MRA (TOF-com) datasets. Bland–Altman analysis (BA) and intra-class correlation coefficient (ICC) were used to evaluate intra- and inter-observer agreement.

Results

BA revealed the narrowest relative limits of intra- and inter-observer agreement for aneurysm neck and depth diameters obtained by TOF-com (ranging between ±5.3 % and ±28.3 %) and CE-com (ranging between ±23.3 % and ±38.1 %). Direct measurements in DSA, TOF-MRA and CE-MRA showed considerably wider limits of agreement. The highest ICCs were observed for TOF-com and CE-com (ICC values, 0.92 or higher for intra- as well as inter-observer reliability).

Conclusion

Computer-aided aneurysm measurement in 3D offers improved intra- and inter-observer reliability and a reproducible parameter extraction, which may be used in clinical routine and as objective surrogate end-points in clinical trials.

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Conflict of interest

JF has received speakers’ fees from Bayer, Boehringer, Boston Scientific, Bracco, Codman, Cordis, ev3, Micrus, Philips, Sanafi, Siemens and Stryker, and has been financially supported by DFG, EU and BMBF. JHB has received speakers’ fees from Codman. Funding sources had no influence on the acquisition, analysis or interpretation of the data.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    M. Groth, J. H. Buhk, M. Schoenfeld, E. Goebell & J. Fiehler

  2. Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    N. D. Forkert

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  1. M. Groth
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  2. N. D. Forkert
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  3. J. H. Buhk
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  4. M. Schoenfeld
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  5. E. Goebell
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  6. J. Fiehler
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Correspondence to M. Groth.

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Groth, M., Forkert, N.D., Buhk, J.H. et al. Comparison of 3D computer-aided with manual cerebral aneurysm measurements in different imaging modalities. Neuroradiology 55, 171–178 (2013). https://doi.org/10.1007/s00234-012-1095-8

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  • DOI: https://doi.org/10.1007/s00234-012-1095-8

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