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The incidence and clinical predictors of acute infarction in patients with transient ischemic attack using MRI including DWI

  • Diagnostic Neuroradiology
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Abstract

Introduction

According to the most recent definition of transient ischemic attack (TIA) and the recommendations of the American Heart Association, magnetic resonance imaging (MRI) including diffusion-weighted imaging (DWI) is considered a mandatory tool in evaluating and treating patients with TIA. This study aims to determine the incidence of TIA-related acute infarction, identify the independent predictors of acute infarction, and investigate the correlation between acute infarction detected by DWI-MRI and stroke risk during hospitalization.

Methods

Over a 36-month period (starting November 2007), all TIA patients (symptom duration of <24 h) who were admitted to hospital within 48 h of symptom onset and who underwent DWI-MRI were included in this population-based prospective study. The incidence of acute infarction, clinical predictors, and association with stroke recurrence during hospitalization were studied.

Results

Of 1,910 patients (mean age, 66.7 ± 13 years; 46 % women), 1,862 met the inclusion criteria. A TIA-related acute infarction was detected in 206 patients (11.1 %). Several independent predictors were identified with logistic regression analysis: motor weakness [odds ratio (OR), 1.5], aphasia (OR, 1.6), National Institutes of Health Stroke Scale (NIHSS) score of ≥10 at admission (OR, 3.2), and hyperlipidemia (OR, 0.6). Of 24 patients (1.3 %) who suffered a stroke during hospitalization (mean, 6 ± 4 days), five had positive DWI. Stroke rate during hospitalization was nonsignificantly higher in patients with positive DWI than those with negative DWI (2.4 vs 1.1 %, respectively; P = 0.12).

Conclusion

The evidence of acute infarction by DWI-MRI in TIA patients was detected in 11.1 % of patients and associated with motor weakness, aphasia, and NIHSS score of ≥10 at admission.

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Mohamed Al-Khaled, Thomas F. Münte & Jürgen Eggers

  2. Institute of Social Medicine, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Christine Matthis

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  1. Mohamed Al-Khaled
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Correspondence to Mohamed Al-Khaled.

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Al-Khaled, M., Matthis, C., Münte, T.F. et al. The incidence and clinical predictors of acute infarction in patients with transient ischemic attack using MRI including DWI. Neuroradiology 55, 157–163 (2013). https://doi.org/10.1007/s00234-012-1091-z

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