, Volume 54, Issue 7, pp 771–780 | Cite as

In vivo evaluation of white matter pathology in patients of progressive supranuclear palsy using TBSS

  • Jitender Saini
  • Bhavani Shankara Bagepally
  • Mangalore Sandhya
  • Shaik Afsar Pasha
  • Ravi Yadav
  • Pramod Kumar PalEmail author
Functional Neuroradiology



The purpose of this research is to study white matter (WM) changes in patients of progressive supranuclear palsy (PSP) using automated analysis of diffusion tensor imaging (DTI) indices.


This was a prospective study comprising of 24 patients of PSP and 26 matched healthy controls. Fractional anisotropy, mean diffusivity (MD), axial diffusivity, and radial diffusivity (RD) changes were studied in the WM of the PSP patients using an automated analysis technique, tract-based spatial statistics (TBSS). Two subtypes of PSP, i.e., classic Richardson’s syndrome (PSP-RS) and parkinsonian type (PSP-P), were also compared among themselves to identify relative severity of WM changes as well as identify spatial distribution of the differences. Clinicoradiological correlation was done to determine the strength of correlation between WM abnormalities identified using TBSS and clinical scores.


There were areas of significant abnormality seen in the frontoparietal cerebral WM, thalamus, midbrain tectum, superior cerebellar peduncle, and cerebellar WM. The abnormalities were more spatially widespread on MD and RD maps. Compared to PSP-P, the patients of PSP-RS had more spatial abnormalities localized to the frontal WM. There was no correlation between the observed WM changes and clinical rating scales.


The TBSS analysis showed widespread WM abnormalities in PSP patients including areas which have been shown to be involved in previous pathological studies. PSP-RS showed more severe white matter abnormality compared to the PSP-P subtype.


Progressive supranuclear palsy DTI TBSS 



BSB acknowledges Indian Council for Medical Research for PhD financial support.

Conflict of interest

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Jitender Saini
    • 1
  • Bhavani Shankara Bagepally
    • 1
  • Mangalore Sandhya
    • 1
  • Shaik Afsar Pasha
    • 2
  • Ravi Yadav
    • 2
  • Pramod Kumar Pal
    • 2
    Email author
  1. 1.Department of Neuroimaging and Interventional RadiologyNational Institute of Mental Health & NeurosciencesBangaloreIndia
  2. 2.Department of NeurologyNational Institute of Mental Health & NeurosciencesBangaloreIndia

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