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Correlation of aneurysm occlusion with actual metal coverage at neck after implantation of flow-diverting stent in rabbit models

Neuroradiology volume 54, pages 607–613 (2012)Cite this article

Abstract

Introduction

A remarkable curing rate has been achieved in the treatment of intracranial intractable aneurysms by using flow-diverting stents (FDS). An appropriate metal coverage (MC) of this device influences the hemodynamics of aneurysm significantly but little to branches in vitro. The MC changes after elongation or compression and the actual changes are still unknown in vivo. In this paper, we analyzed the correlation of aneurysm occlusion with actual MC after implantation of FDS in rabbit models.

Methods

FDS was implanted across the necks of 22 elastase-induced aneurysms in rabbits. Animals were performed for angiography at 4 weeks and sacrificed at 3 months after angiography for pathology. Tissue was explanted with stent for micro-computed tomography scan, and local shape of stent at neck was reconstructed. Actual MC at neck was calculated, and the correlations of aneurysm occlusion with effective factors were analyzed.

Results

Greater than 95% angiographic aneurysm occlusion rates for the FDS, which covered the neck of aneurysms, were 61.9% at 4 weeks and 57.9% by angiography at 3 months. Aneurysm occlusion was positively correlated with local MC of stent at neck (r s = 0.486; P = 0.026). A 35% actual MC at the neck predicted greater than 95% angiographic aneurysm occlusion with a specificity of 100% and sensitivity of 53.8%.

Conclusion

Aneurysm occlusion was positively correlated with local MC of stent at the neck. The FDS with 35% MC can predict greater than 95% angiographic aneurysm occlusion.

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (Grant No. 30901556) and Shanghai Committee of Science and Technology Foundation (Grant No. 08JC1406400). We gratefully thank MicroPort Medical (Shanghai) Co. Ltd. for the free flow-diverting stents.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Changhai Road 168, Shanghai, 200433, People’s Republic of China

    Kuizhong Wang, Qinghai Huang, Bo Hong, Zhen Li, Xinggen Fang & Jianmin Liu

  2. Department of Neurosurgery, General Hospital of Jinan Military Region, Jinan, China

    Kuizhong Wang

Authors
  1. Kuizhong Wang
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  2. Qinghai Huang
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  3. Bo Hong
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  4. Zhen Li
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  5. Xinggen Fang
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  6. Jianmin Liu
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Corresponding author

Correspondence to Jianmin Liu.

Additional information

Dr. Kuizhong Wang and Bo Hong are co-first authors.

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Wang, K., Huang, Q., Hong, B. et al. Correlation of aneurysm occlusion with actual metal coverage at neck after implantation of flow-diverting stent in rabbit models. Neuroradiology 54, 607–613 (2012). https://doi.org/10.1007/s00234-011-0922-7

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  • DOI: https://doi.org/10.1007/s00234-011-0922-7

Keywords

  • Aneurysm
  • Flow-diverting stent
  • Metal coverage
  • Rabbit