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Diffusion tensor imaging of peripheral nerve in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a feasibility study

  • Diagnostic Neuroradiology
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Abstract

Introduction

The purpose of this study was to assess the clinical feasibility of diffusion tensor imaging (DTI) for the evaluation of peripheral nerves in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).

Methods

Using a 3-T magnetic resonance imaging scanner, we obtained DTI scans of the tibial nerves of 10 CIDP patients and 10 sex- and age-matched healthy volunteers. We prepared fractional anisotropy (FA) maps, measured the FA values of tibial nerves, and compared these values in the two study groups. In nine patients, we also performed tibial nerve conduction studies and analyzed the correlation between the FA values and parameters of the nerve conduction study.

Results

The tibial nerve FA values in CIDP patients (median 0.401, range 0.312–0.510) were significantly lower than those in healthy volunteers (median 0.530, range 0.469–0.647) (Mann–Whitney test, p < 0.01). They were significantly correlated with the amplitude of action potential (Spearman correlation coefficient, p = 0.04, r = 0.86) but not with nerve conduction velocity (p = 0.79, r = 0.11).

Conclusion

Our preliminary data suggest that the noninvasive DTI assessment of peripheral nerves may provide useful information in patients with CIDP.

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Takako Kakuda, Hiroshi Fukuda, Keizo Tanitame, Miyuki Takasu, Shuji Date & Kazuo Awai

  2. Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical Science, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Kazuhide Ochi, Tomohiko Ohshita & Masayasu Matsumoto

  3. Department of Neurology, Hiroshima City Hospital, 7-33, Moto-machi, Naka-ku, Hiroshima, 730-8518, Japan

    Tatsuo Kohriyama

  4. Department of Radiology, Onomichi General Hospital, 7-19, Kohama-cho, Onomichi, Hiroshima-ken, 722-8508, Japan

    Katsuhide Ito

Authors
  1. Takako Kakuda
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  2. Hiroshi Fukuda
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  3. Keizo Tanitame
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  4. Miyuki Takasu
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  5. Shuji Date
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  6. Kazuhide Ochi
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  7. Tomohiko Ohshita
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  8. Tatsuo Kohriyama
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  9. Katsuhide Ito
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  10. Masayasu Matsumoto
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  11. Kazuo Awai
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Corresponding author

Correspondence to Hiroshi Fukuda.

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Kakuda, T., Fukuda, H., Tanitame, K. et al. Diffusion tensor imaging of peripheral nerve in patients with chronic inflammatory demyelinating polyradiculoneuropathy: a feasibility study. Neuroradiology 53, 955–960 (2011). https://doi.org/10.1007/s00234-010-0833-z

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  • DOI: https://doi.org/10.1007/s00234-010-0833-z

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