Abstract
Introduction
Change in tumor size is a frequent endpoint in cancer clinical trials, but whether change in size should be measured using volume on two-dimensional (2D) or three-dimensional (3D) images is not certain. We compared volumetric measurements on post-contrast 2D and high-resolution 3D T1-weighted MR images (T1WI) in evaluating tumor response in glioblastoma multiforme (GBM).
Methods
Tumor volume measurements were performed on 86 MRI studies from 37 adult patients with GBM on post-contrast 5 mm 2D T1WI and isotropic high-resolution T1WI. The means of the two volumes were compared and their association was analyzed.
Results
There is no significant difference between volumes measured on 2D and 3D in 86 scans (Z = 0.63, p = 0.53), and a high correlation was revealed between them (r = 0.95, 95% CI: 0.93–0.97, p < 0.001). When the percentage changes were categorized into traditional tumor response criteria (complete response/partial response/stable disease/progressive disease), the kappa coefficient between the volume on 2D and volume on 3D was 0.80 (95% CI: 0.57–1.03, p < 0.05) with an overall agreement of 84%.
Conclusions
Volume on post-contrast 2D T1WI appears comparable to volume on 3D T1WI and should be a practical alternative to volume on 3D in evaluating tumor response.
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Acknowledgments
We wish to thank Dr. A. Gregory Sorensen in the Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, USA, for technical guidance.
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We declare that we have no conflict of interest.
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Mei-Yun Wang and Jing-Liang Cheng are joint first authors.
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Wang, MY., Cheng, JL., Han, YH. et al. Comparison of volumetric methods for tumor measurements on two and three dimensional MRI in adult glioblastoma. Neuroradiology 53, 565–569 (2011). https://doi.org/10.1007/s00234-010-0789-z
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DOI: https://doi.org/10.1007/s00234-010-0789-z