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Long-term results with Matrix coils vs. GDC: an angiographic and histopathological comparison

Neuroradiology volume 50, pages 693–699 (2008)Cite this article

Abstract

Introduction

The aim of the study was to compare standard platinum Guglielmi detachable coils (GDC) with coated platinum coils (Matrix; both Boston Scientific, Fremont, CA) regarding handling, complications, occlusion and recanalization rate after 3 and 6 months.

Methods

Aneurysms in the right common carotid artery were created in 25 rabbits. The animals were divided into five groups of five animals each. The animals of group 1 (the control group) received no treatment of the induced aneurysms, the animals of groups 2 and 3 (killed at 3 and 6 months) were treated with standard GDC, and the animals of groups 4 and 5 (killed at 3 and 6 months) were treated with Matrix coils.

Results

Histopathological evaluation showed organized thrombus formation and connective tissue with neovascularization around the implanted coils in all the treated groups. The achieved occlusion rates in groups 2 and 3 were identical to those in groups 4 and 5. Thus the long-term results of aneurysm treatment with GDC and Matrix coils show no differences regarding occlusion and recanalization rates. The only noticeable difference was the difference in handling. More force was required to pushing the Matrix coils forward through the microcatheter and there was more friction in coil interaction in the aneurysm.

Conclusion

The bioactive coating of the Matrix coil produces no significant benefit in achieving higher occlusion and lower recanalization rates, and the coil is more difficult to handle. Future bioactive coils must be shown to produce significantly better long-term results than GDC and their ease of handling has to be improved.

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Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Neuroradiology, University of the Saarland, Homburg, Germany

    C. Roth, I. Q. Grunwald, C. Krick, P. Papanagiotou, P. Krampe & W. Reith

  2. Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany

    T. Struffert

  3. Department of Neuropathology, Friedrich-Schiller University, Jena, Germany

    B. F. M. Romeike

  4. Department of Diagnostic and Interventional Neuroradiology, University Clinic of the Saarland, 66421, Homburg, Germany

    C. Roth

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  1. C. Roth
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  2. T. Struffert
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  3. I. Q. Grunwald
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  4. B. F. M. Romeike
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  5. C. Krick
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  7. P. Krampe
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Correspondence to C. Roth.

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Roth, C., Struffert, T., Grunwald, I.Q. et al. Long-term results with Matrix coils vs. GDC: an angiographic and histopathological comparison. Neuroradiology 50, 693–699 (2008). https://doi.org/10.1007/s00234-008-0392-8

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  • DOI: https://doi.org/10.1007/s00234-008-0392-8

Keywords

  • Experimental aneurysm model
  • GDC
  • Matrix
  • Coil
  • Rabbit