Abstract
Introduction
Atypical/malignant meningiomas recur more frequently then typical meningiomas. In this study, the contribution of diffusion-weighted MR imaging to the differentiation of atypical/malignant and typical meningiomas and to the determination of histological subtypes of typical meningiomas was investigated.
Methods
The study was performed prospectively on 39 patients. The signal intensity of the lesions was evaluated on trace and apparent diffusion coefficient (ADC) images. ADC values were measured in the lesions and peritumoral edema. Student’s t-test was used for statistical analysis. P<0.05 was considered statistically significant.
Results
Mean ADC values in atypical/malignant and typical meningiomas were 0.75±0.21 and 1.17±0.21, respectively. Mean ADC values for subtypes of typical meningiomas were as follows: meningothelial, 1.09±0.20; transitional, 1.19±0.07; fibroblastic, 1.29±0.28; and angiomatous, 1.48±0.10. Normal white matter was 0.91±0.10. ADC values of typical meningiomas and atypical/malignant meningiomas significantly differed (P<0.001). However, the difference between peritumoral edema ADC values was not significant (P>0.05). Furthermore, the difference between the subtypes of typical meningiomas and atypical/malignant meningiomas was significant (P<0.001).
Conclusion
Diffusion-weighted MR imaging findings of atypical/malignant meningiomas and typical meningiomas differ. Atypical/malignant meningiomas have lower intratumoral ADC values than typical meningiomas. Mean ADC values for peritumoral edema do not differ between typical and atypical meningiomas.
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References
Kleihues P, Cavenee WK (eds) (2000) Pathology and genetics of tumours of the nervous system. IARC Press, Lyon
Buetow MP, Buetow PC, Smirniotopoulos JG (1991) Typical, atypical and misleading features in meningioma. Radiographics 11:1087–1106
Perry A, Scheithauer BW, Stafford SL, Abell-Aleff PC, Meyer FB (1997) Meningioma grading: an analysis of histologic parameters. Am J Surg Pathol 21:1455–1465
Verheggen R, Finkenstaedt M, Bockermann V, Markakis E (1996) Atypical and malignant meningiomas: evaluation of different radiological criteria based on CT and MRI. Acta Neurochir (Wien) 65:66–69
Maier H, Ofner D, Hittmair A, Kitz K, Budka H (1992) Classic, atypical, and anaplastic meningioma: three histopathological subtypes of clinical relevance. J Neurosurg 77:616–623
Carpeggiani P, Crisi G, Trevisan C (1993) MRI of intracranial meningiomas: correlations with histology and physical consistency. Neuroradiology 35:532–536
Bulakbasi N, Guvenc I, Onguru O, Erdogan E, Tayfun C, Ucoz T (2004) The added value of the apparent diffusion coefficient calculation to magnetic resonance imaging in the differentiation and grading of malignant brain tumors. J Comput Assist Tomogr 28:735–746
Krabbe K, Gideon P, Wagn P, Hansen U, Thomsen C, Madsen F (1997) MR diffusion imaging of human intracranial tumours. Neuroradiology 39:483–489
Harting I, Hartmann M, Bonsanto MM, Sommer C, Sartor K (2004) Characterization of necrotic meningioma using diffusion MRI, perfusion MRI, and MR spectroscopy: case report and review of the literature. Neuroradiology 46:189–193
Gomez-Anson B, Munoz A, Blasco A et al (1995) Meningioangiomatosis: advanced imaging and pathological study of two cases. Neuroradiology 37:120–123
Filippi CG, Edgar MA, Ulug AM, Prowda JC, Heier LA, Zimmerman RD (2001) Appearance of meningiomas on diffusion-weighted images: correlating diffusion constants with histopathologic findings. AJNR Am J Neuroradiol 22:65–72
Yamasaki F, Kurisu K, Satoh K et al (2005) Apparent diffusion coefficient of human brain tumors at MR imaging. Radiology 3:985–991
Lobato RD, Alday R, Gomez PA et al (1996) Brain oedema in patients with intracranial meningioma: correlation between clinical, radiological, and histological factors and the presence and intensity of edema. Acta Neurochir 138:485–493
Sugahara T, Korogi Y, Kochi M et al (1999) Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 9:53–60
Vorisek I, Hajek M, Tintera J et al (2002) Water ADC, extracellular space volume, and tortuosity in the rat cortex after traumatic injury. Magn Reson Med 48:994–1003
Szafer A, Zhong J, Anderson AW, Gore JC (1995) Diffusion-weighted imaging in tissues: theoretical models. NMR Biomed 8:289–296
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Hakyemez, B., Yıldırım, N., Gokalp, G. et al. The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomas. Neuroradiology 48, 513–520 (2006). https://doi.org/10.1007/s00234-006-0094-z
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DOI: https://doi.org/10.1007/s00234-006-0094-z