, Volume 47, Issue 10, pp 749–752 | Cite as

Excellent cognitive performance despite massive cerebral white matter changes

  • Thomas DuningEmail author
  • Harald Kugel
  • Stefan Knecht
Diagnostic Neuroradiology


Marked cerebral white matter changes are a frequent finding in the daily routine of magnetic resonance imaging of elderly patients. These findings are often equated with a decrease of cognitive function. Here we present a case of massive white matter changes but excellent cognitive performance, to avoid the automatism of drawing conclusions on intellectual ability by just interpreting the imaging data of elderly patients.


White matter changes Cognitive impairment Leuko-araiosis Cognitive reserve Neuropsychological testing 



This work was supported by the NRW-Nachwuchsgruppe Kn2000 of the Nordrhein-Westfalen Ministry of Education and Research (Fö.1KS9604/0), the Interdisciplinary Centre of Clinical Research, Münster (IZKF Projects FG2 and Kne3/074/04), the Innovative Medizinische Forschung, Münster (KN520301), the Deutsche Forschungsgemeinschaft (Kn 285/6–1 and 6–3) as well as a Marie Curie Research and Training grant (RTN:LAB 512141), Mednet Atrial Fibrillation BMBF, and the Neuromedical Foundation.


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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of MünsterMünsterGermany
  2. 2.Department of Clinical RadiologyUniversity of MünsterMünsterGermany
  3. 3.IZKF MünsterUniversity of MünsterMünsterGermany

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