Abstract
In this prospective MRI study, we evaluated the impact of the site of occlusion on multiple baseline perfusion parameters and subsequent recanalization in 49 stroke patients who were given intravenous tissue plasminogen activator (tPA). Pretreatment magnetic resonance angiography (MRA) revealed an arterial occlusion in 47 patients: (1) internal carotid artery (ICA) + M1 middle cerebral artery (MCA) occlusion (n=12); (2) M1 MCA occlusion (n=19); (3) M2 MCA, distal branches of the MCA and anterior cerebral artery (ACA) occlusion (n=16). Patients with ICA occlusion had significantly larger DWI, PWI and mismatch lesion volume on pretreatment MRI compared to patients with other sites of occlusion. The differences in cerebral blood flow (CBF) and peak height were significantly higher in patients with ICA occlusion compared to patients with other sites of occlusion (P=0.03 and P=0.04, respectively). Day 1 MRA showed recanalization in 28 patients (60%). The rate of recanalization was significantly different depending on the site of occlusion: 33% in ICA + M1 MCA occlusion, 63% in M1 MCA occlusion and 81% in either M2 MCA, distal branches of the MCA or ACA occlusion (P=0.002). Our data suggest that CBF and peak height are the most relevant MRI parameters to assess the severity of hemodynamic impairment in regard to the site of occlusion.
Similar content being viewed by others
References
Schellinger PD, Fiebach JB, Jansen O, Ringleb PA, Mohr A, Steiner T, Heiland S, Schwab S, Pohlers O, Ryssel H, Orakcioglu B, Sartor K, Hacke W (2001) Stroke magnetic resonance imaging within 6 hours after onset of hyperacute cerebral ischemia. Ann Neurol 49:460–469
Linfante I, Llinas RH, Selim M, Chaves C, Kumar S, Parker RA, Caplan LR, Schlaug G (2002) Clinical and vascular outcome in internal carotid artery versus middle cerebral artery occlusions after intravenous tissue plasminogen activator. Stroke 33:2066–2071
Röther J, Schellinger PD, Gass A, Siebler M, Villringer A, Fiebach JB, Fiehler J, Jansen O, Kucinski T, Schoder V, Szabo K, Junge-Hülsing GJ, Hennerici M, Zeumer H, Sartor K, Weiller C, Hacke W, Kompetenznetzwerk Schlaganfall Study Group (2002) Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 hours. Stroke 33:2438–2445
Brott TG, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V, Rorick M, Moomaw CJ, Walker M (1989) Measurements of acute cerebral infarction. A clinical examination scale. Stroke 20:864–870
Neumann-Haefelin T, Wittsack HJ, Fink GR, Wenserski F, Li TQ, Seitz RJ, Siebler M, Mödder U, Freund HJ (2000) Diffusion- and perfusion-weighted MRI. Influence of severe carotid artery stenosis on the DWI/PWI mismatch in acute stroke. Stroke 31:1311–1317
Nighoghossian N, Hermier M, Adeleine P, Derex L, Dugor JF, Philippeau F, Ylmaz H, Honnorat J, Dardel JP, Berthezène Y, Froment JC, Trouillas P (2003) Baseline magnetic resonance imaging parameters and stroke outcome in patients treated by intravenous tissue plasminogen activator. Stroke 34:458–463
Ostergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR (1996a) High resolution measurement of cerebral blood flow using intravascular tracer bolus passages, part I: mathematical approach and statistical analysis. Magn Reson Med 36:715–725
Ostergaard L, Sorensen AG, Kwong KK, Weisskoff RM, Gyldensted C, Rosen BR (1996b) High resolution measurement of cerebral blood flow using intravascular tracer bolus passages, part II: experimental comparison and preliminary results. Magn Reson Med 36:726–736
Marks MP, Tong DC, Beaulieu C, Albers GW, de Crespigny A, Moseley ME (1999) Evaluation of early reperfusion and IV tPA therapy using diffusion- and perfusion-weighted MRI. Neurology 52:1792–1798
Van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJA, Van Gijn J (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19:604–607
Trouillas P, Nighoghossian N, Derex L, Adeleine P, Honnorat J, Neuschwander P, Riche G, Getenet JC, Li W, Froment JC, Turjman F, Malicier D, Fournier G, Gabry AL, Ledoux X, Berthezène Y, Ffrench P, Dechavanne M (1998) Thrombolysis with intravenous rtPA in a series of 100 cases of acute carotid territory stroke. Determination of etiological, topographic and radiological outcome factors. Stroke 29: 2529–2540
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581–1587
Mori E, Yoneda Y, Tabuchi M, Yoshida T, Ohkawa S, Oshumi Y, Kitano K, Tutsumi A, Yamadori A (1992) Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology 42:976–982
Del Zoppo G, Poeck K, Pessin M, Wolpert SM, Furlan AJ, Ferbert A, Alberts MJ, Zivin JA, Wechsler L, Busse O, Greenlee R, Brass L, Mohr JP, Feldman E, Hacke W, Higashida RT, Gent M, Rowley H, Ahuja A, Callahan F, Clark WM, Kase C, Biller J, Gress D, Otis SM (1992) Recombinant tissue plasminogen activator in acute thrombotic or embolic stroke. Ann Neurol 32:78–86
Rordorf G, Koroshetz WJ, Copen WA, Cramer SC, Schaefer PW, Budzik RF Jr, Schwamm LH, Buonanno F, Sorensen AG, Gonzalez G (1998) Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI. Stroke 29:939–943
Barber PA, Davis SM, Darby DG, Desmond PM, Gerraty RP, Yang Q, Jolley D, Donnan GA, Tress BM (1999) Absent middle cerebral artery flow predicts the presence and evolution of the ischemic penumbra. Neurology 52:1125–1132
Sorensen AG, Copen WA, Ostergaard L, Buonanno FS, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Koroshetz WJ (1999) Hyperacute stroke: simultaneous measurement of relative cerebral blood volume, relative cerebral blood flow and mean transit time. Radiology 210:519–527
Grandin CB, Duprez TP, Smith AM, Oppenheim C, Peeters A, Robert AR, Cosnard G (2002) Which MR-derived perfusion parameters are the best predictors of infarct growth in hyperacute stroke? Comparative study between relative and quantitative measurements. Radiology 223:361–370
Acknowledgements
The authors thank Michèle Canova for her help in collecting and processing the data.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Derex, L., Hermier, M., Adeleine, P. et al. Influence of the site of arterial occlusion on multiple baseline hemodynamic MRI parameters and post-thrombolytic recanalization in acute stroke. Neuroradiology 46, 883–887 (2004). https://doi.org/10.1007/s00234-004-1279-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00234-004-1279-y