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ADC mapping of the aging frontal lobes in mild cognitive impairment

  • Diagnostic Neuroradiology
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Abstract

Normal aging, leukoaraiosis (LA) and vascular disease particularly involve the human frontal lobes. We decided to investigate a population of elderly patients referred for neuroimaging because of progressive minor cognitive deficits but no dementia. They underwent conventional Magnetic resonance imaging (MRI) using axial T1 and T2-weighted imaging as well as coronal FLAIR sequences in addition to the axial diffusion-weighted MRI. MRI allowed us to differentiate patients with leukoaraïosis (LA+) from those without it (LA-) and mapping of the apparent diffusion coefficient (ADC) to investigate local tissular water motion.We observed an increase in the ADC in all investigated patients with increasing age (r=0.326, p=0.002). This increase was observed in both patients groups (LA+ and LA-) . In addition, the LA+ group had significant higher ADC values than the LA- group after controlling for age (p<0.0001).

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Authors and Affiliations

  1. Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211, Geneva, Switzerland

    K. O. Lövblad, J. Delavelle, S. Wetzel, A. D. Kelekis, H. Yilmaz, D. San Millan Ruiz, F. Lazeyras, A. Mehdizade & D. A. Rüfenacht

  2. Clinique de Neurologie, Hôpital Universitaire de Genève, Geneva, Switzerland

    F. Assal & M. Palmesino

  3. Service de Gériatrie, Hôpital Belle-Idée, Geneva, Switzerland

    G. Gold

Authors
  1. K. O. Lövblad
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  2. J. Delavelle
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  3. S. Wetzel
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  4. A. D. Kelekis
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  5. F. Assal
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  6. M. Palmesino
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  7. G. Gold
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  8. H. Yilmaz
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  9. D. San Millan Ruiz
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  10. F. Lazeyras
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  11. A. Mehdizade
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  12. D. A. Rüfenacht
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Correspondence to K. O. Lövblad.

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Lövblad, K.O., Delavelle, J., Wetzel, S. et al. ADC mapping of the aging frontal lobes in mild cognitive impairment. Neuroradiology 46, 282–286 (2004). https://doi.org/10.1007/s00234-004-1183-5

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  • DOI: https://doi.org/10.1007/s00234-004-1183-5

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