Neuroradiology

, Volume 46, Issue 5, pp 359–362 | Cite as

Functional MRI in healthy subjects during acupuncture: different effects of needle rotation in real and false acupoints

  • J. L. Fang
  • T. Krings
  • J. Weidemann
  • I. G. Meister
  • A. Thron
Diagnostic Neuroradiology

Abstract

The cerebral activation pattern due to acupuncture is not completely understood. Although the effect of acupuncture on cerebral haemodynamics has been studied, no previous report has focused on different puncture and stimulation methods. We used functional MRI (fMRI) in 15 healthy subjects to investigate cortical activation during stimulation of two real acupoints (Liv3 and G40) and one sham point, needled in a random and, for the subjects, blinded order employing rotating and non-rotating methods, using a blocked paradigm on a 1.5 tesla imager. Compared to the non-rotating stimulation method, during rotating stimulation of the real acupoints, we observed an increase in activation in both secondary somatosensory cortical areas, frontal areas, the right side of the thalamus and the left side of the cerebellum; no such effects of the needling technique were seen while stimulating the sham point. The observation that rotating the needle strengthened the effects of acupuncture only at real acupoints suggests that, as claimed in Chinese traditional medicine, stimulation of these acupoints has a specific effect on cortical neuronal activity, absent with sham acupoints. These specific cerebral activation patterns might explain the therapeutic effects of acupuncture in certain subjects.

Key words

Functional magnetic resonance imaging Acupuncture analgesia 

References

  1. 1.
    Zhang EQ (1990) Chinese acupuncture and moxibustion. Shanghai University of Traditional Chinese Medicine, Shanghai, pp 2–56Google Scholar
  2. 2.
    Cheng XN (1987) Chinese acupuncture and moxibustion. Foreign Language Press, Peking, pp 1–216Google Scholar
  3. 3.
    Anon (1997) NIH Consensus Statement on Acupuncture. National Institutes of Health, BethesdaGoogle Scholar
  4. 4.
    Han JS (1982) Neurochemical basis of acupuncture. Ann Rev Pharmacol Toxicol 22: 193–220CrossRefGoogle Scholar
  5. 5.
    Melzack R (1994) Folk medicine and the sensory modulation of pain. In: Wall PD, Melzack R (eds) The textbook of pain, 3rd edn. Churchill Livingstone, London, pp 1209–1218Google Scholar
  6. 6.
    Pomeranz B (1995) Scientific basis of acupuncture. In: Stux G, Pomeranz B (eds) Basics of acupuncture, 3rd edn. Springer-Verlag, New York, pp 4–60Google Scholar
  7. 7.
    Filshie J, White A (1998) Medical acupuncture: a Western scientific approach. Churchill Livingstone, LondonGoogle Scholar
  8. 8.
    Hui KKS, Liu J, Makris N, et al (2000) Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects. Hum Brain Mapping 9: 13–25CrossRefGoogle Scholar
  9. 9.
    Wu MT, Hsieh JC, Xiong H, et al (1999) Central nervous pathway for acupuncture stimulation: localization of processing with functional MR imaging of the brain—preliminary experience. Radiology 212: 133–141PubMedGoogle Scholar
  10. 10.
    Biella G, Sotgiu ML, Pellegata G, et al (2001) Acupuncture produces central activations in pain regions. Neuroimage 14: 60–66CrossRefPubMedGoogle Scholar
  11. 11.
    Hsieh J, Tu C, Chen M, et al (2001) Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study. Neurosci Lett 307: 105–108CrossRefPubMedGoogle Scholar
  12. 12.
    Wu MT, Sheen JM, Chuang KH, et al (2002) Neuronal specificity of acupuncture response: an fMRI study with electroacupuncture. Neuroimage 16: 1028–1037CrossRefPubMedGoogle Scholar
  13. 13.
    Cho ZH, Chung SC, Jones JP, et al (1998) New findings of the correlation between acupoints and corresponding brain cortices using functional MRI. Proc Natl Acad Sci USA 95: 2670–2673CrossRefPubMedGoogle Scholar
  14. 14.
    Cho ZH, Na CS, Wang EK, et al (2001) FMRI of the brain in the investigation of acupuncture. In Stux G, Hammerschlag R (eds) Clinical acupuncture—scientific basis. Springer-Verlag, Berlin, pp 83–96Google Scholar
  15. 15.
    Siedentopf CM, Golaszewski SM, Mottaghy FM, et al (2002) fMRI detects activation of the visual association cortex during laser acupuncture of the foot in humans. Neurosci Lett 327: 53–56CrossRefPubMedGoogle Scholar
  16. 16.
    Friston KJ, Holmes AP, Price CJ, Buchel C, Worsley KJ (1999) Multisubject fMRI studies and conjunction analyses. Neuroimage 10: 385–396CrossRefPubMedGoogle Scholar
  17. 17.
    Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Thieme, New YorkGoogle Scholar
  18. 18.
    Liu X (1996) The modulation of cerebral cortex and subcortical nuclei on NRM and their role in acupuncture analgesia [Chinese]. Acupuncture Res 21: 4–11Google Scholar
  19. 19.
    Price DD (2000) Psychological and neural mechanisms of the affective dimension of pain. Science 288: 1769–1772CrossRefPubMedGoogle Scholar
  20. 20.
    Han JS (1999) Principles in neuroscience, 2nd edn. Beijing Medical University, Beijing, pp 728–971Google Scholar
  21. 21.
    Jiang WQ, Liu X (1994) The lesion of somatosensory area II of cerebral cortex reducing the effects of electroacupuncture of “zusanli” on nucleus raphe magnus in rats [Chinese]. Acupuncture Res 19: 4–7Google Scholar
  22. 22.
    Liu X, Zhu B (1986) Relationship between electroacupuncture analgesia and descending pain inhibitory mechanism of nucleus raphe magnus. Pain 24: 5675–5679Google Scholar
  23. 23.
    Richardson PH, Vincent PA (1986) Acupuncture for the treatment of pain: a review of evaluative research. Pain 24: 15–40CrossRefPubMedGoogle Scholar
  24. 24.
    Vincent PA, Richardson PH (1986) The evaluation of therapeutic acupuncture: concepts and models. Pain 24: 1–13CrossRefPubMedGoogle Scholar
  25. 25.
    Vincent PA, Richardson PH, Black JJ, Pither CE (1989) The significance of needle placement site in acupuncture. J. Psychosom Res 33: 489–496CrossRefGoogle Scholar
  26. 26.
    Vincent PA, Lewith G (1995) Placebo controls for acupuncture studies. J Roy Soc Med 88: 199–202Google Scholar
  27. 27.
    Liu W, Zhu W (1999) A study on standardisation of methods and manipulations in acupuncture [Chinese]. J Clin Acupuncture Moxibustion 15: 2–3Google Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • J. L. Fang
    • 1
  • T. Krings
    • 2
  • J. Weidemann
    • 2
  • I. G. Meister
    • 3
  • A. Thron
    • 2
  1. 1.Department of RadiologyGuang An Men Hospital, China Academy of Traditional Chinese MedicinePekingChina
  2. 2.Department of NeuroradiologyUniversity Hospital of the University of Technology, AachenAachenGermany
  3. 3.Department of NeurologyUniversity Hospital of the University of Technology, AachenAachenGermany

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