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Contrast enhancement in Lhermitte–Duclos disease of the cerebellum: correlation of imaging with neuropathology in two cases

  • Diagnostic Neuroradiology
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Abstract

Lhermitte–Duclos disease (LDD), also known as dysplastic gangliocytoma, is a rare cerebellar lesion. It has long been regarded as avascular. We report two patients with surgically proven LDD in whom contrast enhancement was observed on MRI. Neuropathological examination revealed proliferation of veins. We suggest that peripheral enhancement of LDD probably reflects vascular proliferation of the cerebellar venous draining system, and should be considered part of the imaging features of LDD.

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Fig. 2 a–f.

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Authors and Affiliations

  1. Department of Radiology, Universitair Ziekenhuis Antwerpen, University of Antwerp, Wilrijkstraat 10, 2650 , Edegem, Belgium

    L. Spaargaren, J. W. Van Goethem, O. Ozsarlak, A. M. De Schepper & P. M. Parizel

  2. Department of Neurology, Universitair Ziekenhuis Antwerpen, University of Antwerp, Wilrijkstraat 10, 2650 , Edegem, Belgium

    P. Cras

  3. Department of Neurology, Amphia Ziekenhuis Breda, Molengracht 21, 4818 CK , Breda, The Netherlands

    M. A. M. Bomhof

  4. Department of Neurosurgery, Elisabeth Ziekenhuis Tilburg, Hilvarenbeekseweg 60, 5022 GC , Tilburg, The Netherlands

    S. T. Lie

  5. Department of Neurology, Algemeen Ziekenhuis KLINA, Augustijnslei 100, 2930 , Brasschaat, Belgium

    A. M. de Barsy

  6. Department of Neurosurgery, Algemeen Ziekenhuis KLINA, Augustijnslei 100, 2930 , Brasschaat, Belgium

    P. H. Croese

  7. Department of Neuropathology, Elisabeth Ziekenhuis Tilburg, Hilvarenbeekseweg 60, 5022 GC , Tilburg, The Netherlands

    J. L. J. M. Teepen

  8. Department of Pathology, Algemeen Ziekenhuis KLINA, Augustijnslei 100, 2930 , Brasschaat, Belgium

    V. H. J. M. Duwel

  9. Department of Radiology, Algemeen Ziekenhuis KLINA, Augustijnslei 100, 2930 , Brasschaat, Belgium

    L. van den Hauwe

Authors
  1. L. Spaargaren
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  2. P. Cras
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  3. M. A. M. Bomhof
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  4. S. T. Lie
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  5. A. M. de Barsy
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  6. P. H. Croese
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  7. J. L. J. M. Teepen
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  8. V. H. J. M. Duwel
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  9. J. W. Van Goethem
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  10. O. Ozsarlak
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  11. L. van den Hauwe
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  12. A. M. De Schepper
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  13. P. M. Parizel
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Corresponding author

Correspondence to P. M. Parizel.

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Spaargaren, L., Cras, P., Bomhof, M.A.M. et al. Contrast enhancement in Lhermitte–Duclos disease of the cerebellum: correlation of imaging with neuropathology in two cases. Neuroradiology 45, 381–385 (2003). https://doi.org/10.1007/s00234-003-0984-2

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  • DOI: https://doi.org/10.1007/s00234-003-0984-2

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