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Extensive cortical damage in a case of Creutzfeldt-Jacob disease: clinicoradiological correlations

  • Diagnostic Neuroradiology
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Abstract

MRI demonstrated extensive cortical involvement in a patient with pathologically proven Creutzfeldt-Jacob disease. The whole brain was atrophic; some of the supratentorial cortex, putamen and caudate nucleus gave high signal on T2-weighted images; the changes were more extensive on diffusion-weighted images (DWI). Comparison of the history, and the sites of atrophy and signal change suggested that the latter predominates in regions with long-lasting damage and prevalent gliosis, while high signal on DWI indicate current neuronal loss. This case widens the range of MRI findings in patients with Creutzfeldt-Jacob disease, and suggests that some information about the progression of the disease can be extracted from single MRI study.

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Authors and Affiliations

  1. Neuroradiology, Ospedale S. G. Battista, University of Torino, Via Cherasco 15, 10126, Torino, Italy

    M. Bergui & G. B. Bradac

  2. Neurology, Ospedale S. G. Battista, University of Torino, Via Cherasco 15, 10126, Torino, Italy

    L. Orsi

  3. Neuropathology Department, Istituto Neurologico C. Besta, Milano, Italy

    G. Rossi

Authors
  1. M. Bergui
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  2. G. B. Bradac
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  3. G. Rossi
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  4. L. Orsi
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Correspondence to G. B. Bradac.

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Bergui, M., Bradac, G.B., Rossi, G. et al. Extensive cortical damage in a case of Creutzfeldt-Jacob disease: clinicoradiological correlations. Neuroradiology 45, 304–307 (2003). https://doi.org/10.1007/s00234-003-0939-7

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  • DOI: https://doi.org/10.1007/s00234-003-0939-7

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