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Activation Kinetics of the K+ Outward Rectifying Conductance (KORC) in Xylem Parenchyma Cells from Barley Roots

Abstract.

The activation kinetics of outward currents in protoplasts from barley root xylem parenchyma was investigated using the patch-clamp technique. The K+ outward rectifying conductance (KORC), providing the main pathway for K+ transport to the xylem, could be described in terms of a Hodgkin-Huxley model with four independent gates. Gating of KORC depended on voltage and the external K+ concentration. An increase in the external K+ concentration resulted in a shift in the voltage dependence of gating. This could be explained by a K+ dependence of the rate constant β for channel closure, indicating binding of K+ to a regulatory site exposed to the bath. Occasionally, KORC was observed to inactivate; this inactivation occurred and vanished spontaneously. In some of the whole cell and excised patch recordings, a stepwise increase in outward current was observed upon a depolarizing voltage pulse, indicating that several populations of `sleepy' channels existed in the plasma membrane that activated with a certain lag time. It is discussed whether this observation can be explained by a putative subunit, which retards channel activation, or by a scheme of cooperative gating. A quantitative description of outward rectifying K+ channels in xylem parenchyma cells is a major step forward towards a mathematical model of salt transport into the xylem.

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Received: 20 November 1998/Revised: 1 April 1999

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Wegner, L., De Boer, A. Activation Kinetics of the K+ Outward Rectifying Conductance (KORC) in Xylem Parenchyma Cells from Barley Roots. J. Membrane Biol. 170, 103–119 (1999). https://doi.org/10.1007/s002329900541

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  • DOI: https://doi.org/10.1007/s002329900541

  • Key words: Plant ion channel — Hodgkin-Huxley formalism — Cooperative gating — K+ dependent gating