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NAADP: An Emerging Calcium Signaling Molecule

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Abstract.

Cells possess multiple Ca2+ stores and multiple messengers for mobilizing them. In addition to inositol trisphosphate and cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate (NAADP), a metabolite of NADP, is shown to be a potent Ca2+ signaling molecule in both invertebrate and mammalian cells. This article summarizes the recent results of this newly discovered Ca2+ signaling mechanism and explores the implications of the apparent proliferation of Ca2+ messengers.

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Authors and Affiliations

  1. Department of Pharmacology, 6-120 Jackson Hall, 321 Church St. SE, University of Minnesota, Minneapolis MN 55455, USA, , , , , , US

    H.C. Lee

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  1. H.C. Lee
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Received: 11 August 1999/Revised: 21 September 1999

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Lee, H. NAADP: An Emerging Calcium Signaling Molecule. J. Membrane Biol. 173, 1–8 (2000). https://doi.org/10.1007/s002320001001

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  • DOI: https://doi.org/10.1007/s002320001001

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