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Remodeling of the Plasma Membrane by Surface-Bound Protein Monomers and Oligomers: The Critical Role of Intrinsically Disordered Regions

The Journal of Membrane Biology volume 255, pages 651–663 (2022)Cite this article

Abstract

The plasma membrane (PM) of cells is a dynamic structure whose morphology and composition is in constant flux. PM morphologic changes are particularly relevant for the assembly and disassembly of signaling platforms involving surface-bound signaling proteins, as well as for many other mechanochemical processes that occur at the PM surface. Surface-bound membrane proteins (SBMP) require efficient association with the PM for their function, which is often achieved by the coordinated interactions of intrinsically disordered regions (IDRs) and globular domains with membrane lipids. This review focuses on the role of IDR-containing SBMPs in remodeling the composition and curvature of the PM. The ability of IDR-bearing SBMPs to remodel the Gaussian and mean curvature energies of the PM is intimately linked to their ability to sort subsets of phospholipids into nanoclusters. We therefore discuss how IDRs of many SBMPs encode lipid-binding specificity or facilitate cluster formation, both of which increase their membrane remodeling capacity, and how SBMP oligomers alter membrane shape by monolayer surface area expansion and molecular crowding.

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Acknowledgements

We thank Professor John F Hancock and members of the Gorfe, Zhou and Hancock groups for helpful discussions.

Funding

This work was supported by the National Institutes of Health Institute of General Medicine Grant Nos. R01GM124233 and R01GM144836 (to AAG) and R01GM138668 (to YZ).

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Authors and Affiliations

  1. Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin St., Houston, TX, 77030, USA

    Mussie K. Araya, Yong Zhou & Alemayehu A. Gorfe

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  1. Mussie K. Araya
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  2. Yong Zhou
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  3. Alemayehu A. Gorfe
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Contributions

MKA wrote the initial draft; YZ and AAG edited the draft; AAG supervised development of the manuscript; all authors read and approved the final version of the manuscript.

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Correspondence to Alemayehu A. Gorfe.

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Araya, M.K., Zhou, Y. & Gorfe, A.A. Remodeling of the Plasma Membrane by Surface-Bound Protein Monomers and Oligomers: The Critical Role of Intrinsically Disordered Regions. J Membrane Biol 255, 651–663 (2022). https://doi.org/10.1007/s00232-022-00256-8

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