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Crosstalk of Nanosystems Induced Extracellular Vesicles as Promising Tools in Biomedical Applications

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Abstract

Hybrid vesicles are considered as a bridge between natural nanosystems (NNSs) and artificial nanosystems (ANSs). NNSs are extracellular vesicles (EVs), membranous, bio-formed endogenously, which act as endogenous cargoes, and reflecting cellular dynamics. EVs have cellular tropism, permeate tight junctions, and are non-immunogenic. EVs are used as tools in the development of diagnostic and therapeutic agents. ANSs can induce biogenesis of hybrid vesicles as promising smart diagnostic agents, and innovative drug cargoes. EVs can encapsulate small molecules, macromolecules, and ANSs. The manipulation of EVs during biogenesis was suggested for engineering hybrid EVs. This review article highlights the role of ANSs in the biogenesis of NNSs, and introduces hybrid nanosystems research.

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Acknowledgements

The authors extend their appreciation to Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University for funding this work through the research Project Number (G-2017-1).

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Authors and Affiliations

  1. Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

    Gamaleldin I. Harisa & Fars K. Alanazi

  2. Department of Biochemistry, College of Pharmacy, Al-Azhar University (Boys), Nasr City, Cairo, Egypt

    Gamaleldin I. Harisa

  3. Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

    Mohamed M. Badran

  4. Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    Sabry M. Attia

  5. Department of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

    Mohamed M. Badran

  6. Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt

    Sabry M. Attia

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  1. Gamaleldin I. Harisa
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  2. Mohamed M. Badran
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Correspondence to Gamaleldin I. Harisa.

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Harisa, G.I., Badran, M.M., Alanazi, F.K. et al. Crosstalk of Nanosystems Induced Extracellular Vesicles as Promising Tools in Biomedical Applications. J Membrane Biol 250, 605–616 (2017). https://doi.org/10.1007/s00232-017-0003-x

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