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Modulatory Action of α-Tocopherol on Erythrocyte Membrane Adenosine Triphosphatase against Radiation Damage in Oral Cancer

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Abstract

To investigate the possible effects of α-tocopherol on erythrocyte membrane adenosine triphosphatases against radiation damage in oral cancer patients. Adenosine triphosphatase activities were analysed in oral cancer patients before and after radiotherapy (at a dosage of 6000 cGY in five fractions per week for a period of six weeks) and after supplemented with α-tocopherol (400 IU per day for entire period of radiotherapy). The membrane bound enzymes such as Na+/K+-ATPase, Ca2+-ATPase, Mg2+-ATPase and some trace elements were altered in oral cancer patients before and after radiotherapy. Supplemented with α-tocopherol modulates the erythrocyte membrane which is damaged by radiotherapy which suggests that α-tocopherol protects the erythrocyte membrane from radiation damage in oral cancer patients.

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Authors and Affiliations

  1. Department of Biotechnology, Sri Ramachandra University, Chennai, India

    Subramaniam Chitra

  2. Department of Biochemistry and Molecular Biology, University of Madras, Chennai, India

    Subramaniam Chitra & Chennam Srinivasulu Shyamaladevi

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  1. Subramaniam Chitra
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  2. Chennam Srinivasulu Shyamaladevi
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Correspondence to Subramaniam Chitra.

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Chitra, S., Shyamaladevi, C.S. Modulatory Action of α-Tocopherol on Erythrocyte Membrane Adenosine Triphosphatase against Radiation Damage in Oral Cancer. J Membrane Biol 240, 83–88 (2011). https://doi.org/10.1007/s00232-011-9346-x

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  • DOI: https://doi.org/10.1007/s00232-011-9346-x

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