The presence of Kv1.3 voltage-gated potassium channels in rat and human prostate epithelial cells has been previously reported. We examined, by immunohistochemistry, Kv1.3 levels in 10 normal human prostate, 18 benign prostatic hyperplasia (BPH) and 147 primary human prostate cancer (Pca) specimens. We found high epithelial expression of Kv1.3 in all normal prostate, 16 BPH and 77 (52%) Pca specimens. Compared to normal, Kv1.3 levels were reduced in 1 (6%) BPH specimen and in 70 (48%) Pca specimens. We found a significant inverse correlation between Kv1.3 levels and tumor grade (r = −0.25, P = 0.003) as well as tumor stage (r = −0.27, P = 0.001). Study of an additional 30 primary Pca specimens showed that 15 (50%) had reduced Kv1.3 immunostaining compared to matched normal prostate tissue. Our data suggest that in Pca reduced Kv1.3 expression occurs frequently and may be associated with a poor outcome.
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Abdul M., Hoosein N. 2002a. Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. 186:99–105
Abdul M., Hoosein N. 2002b. Voltage-gated potassium ion channels in colon cancer. Oncol. Rep. 9:961–964
Abdul M., Santo A. Hoosein N. 2003. Activity of potassium channel-blockers in breast cancer. Anticancer Res. 23:3347–3351
Conforti L., Petrovic M., Mohammad D., Lee S., Ma Q., Barone S., Filipovich A.H. 2003. Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: A possible role in T cell proliferation. J. Immunol. 170:695–702
Defarias F.P., Stevens S.P., Leonard R.J. 1995. Stable expression of human Kv1.3 potassium channels resets the resting membrane potential of cultured mammalian cells. Receptors Channels 3:273–281
Fraser S.P., Grimes J.A., Diss J.K., Stewart D., Dolly J.O., Djamgoz M.B.A. 2003. Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines: Electro-physiological, pharmacological and molecular characterization. Pfluegers Arch. 446:559–571
Grunnet M., Rasmussen H.B., Hay-Schmidt A., Klaerke D.A. 2003. The voltage-gated potassium channel subunit, Kv1.3, is expressed in epithelia. Biochem. Biophys. Acta 1616:85–94
Kunzelmann K. 2005. Ion channels and cancer. J. Membr. Biol. 205:159–173
Ouadid-Ahidouch H., Van Coppenolle F., Le Bourhis X., Belhaj A., Prevarskaya N. 1999. Potassium channels in rat prostate epithelial cells. FEBS Lett. 459:15–21
Panyi G. 2005. Biophysical and pharmacological aspects of K+ channels in T lymphocytes. Eur. Biophys. J. 34:515–529
Preussat K., Beetz C., Schrey M., Kraft R., Wolfl S., Kalff R. Patt S. 2003. Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas. Neurosci. Lett. 346:33–36
Storey N.M., Gomez-Angelats M., Bortner C.D., Armstrong D.L., Cidlowski J.A. 2003. Stimulation of Kv1.3 potassium channels by death receptors during apoptosis in Jurkat T lymphocytes. J. Biol. Chem. 278:33319–33326
Tricoli J.V., Schoenfeldt M., Conley B.A. 2004. Detection of prostate cancer and predicting progression: Current and future diagnostic markers. Clin. Cancer Res. 10:3943–3953
Vaupel P. 2004. The role of hypoxia-induced factors in tumor progression. Oncologist 9:10–17
Xu J., Koni P.A., Wang P., Li G., Kaczmarek L., Wu Y., Li Y., Flavell R.A., Desir G.V. 2003. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Mol. Genet. 12:551–559
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Abdul, M., Hoosein, N. Reduced Kv1.3 Potassium Channel Expression in Human Prostate Cancer. J Membrane Biol 214, 99–102 (2006). https://doi.org/10.1007/s00232-006-0065-7
- Potassium channel