The Journal of Membrane Biology

, Volume 206, Issue 2, pp 103–116

Omega-3 Fatty Acids and the Regulation of Expression of Endothelial Pro-Atherogenic and Pro-Inflammatory Genes

Article

Abstract

By partially replacing the corresponding omega-6 analogues in membrane phospholipids, omega-3 fatty acids have been shown to decrease the transcriptional activation of genes — e.g., adhesion molecules, chemoattractants, inflammatory cytokines — involved in endothelial activation in response to inflammatory and pro-atherogenic stimuli. This regulation occurs, at least in part, through a decreased activation of the nuclear factor-κB system of transcription factors, secondary to decreased generation of intracellular hydrogen peroxide. Such regulation by omega-3 fatty acids is likely linked to the presence of a higher number of double bonds in the fatty acid chain in omega-3 compared with omega-6 fatty acids. By similar mechanisms, omega-3 fatty acids have been recently shown to reduce gene expression of cyclooxygenase-2, an inflammatory gene involved, through the activation of some metalloproteinases, in plaque angiogenesis and plaque rupture. The quenching of gene expression of pro-inflammatory pro-atherogenic genes by omega-3 fatty acids has consequences on the extent of leukocyte adhesion to vascular endothelium, early atherogenesis and later stages of plaque development and plaque rupture, ultimately yielding a plausible comprehensive explanation for the vasculoprotective effects of these nutrients.

Keywords

Omega-3 fatty acids n-3 fatty acids Adhesion molecules Endothelium Endothelial activation Leukocyte adhesion Monocytes Atherosclerosis Cytokines Cyclooxygenase-2 Matrix metalloproteinases Plaque rupture 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Chair of Cardiology, “G. d’Annunzio” UniversityChieti, and C.N.R. Institute of Clinical PhysiologyPisa
  2. 2.Chair of Cardiology, “G. d’Annunzio” UniversityChieti, and C.N.R. Institute of Clinical PhysiologyPisaItaly

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