A mathematical analysis of drug dissolution in the USP flow through apparatus
- 83 Downloads
This paper applies boundary layer theory to the process of drug dissolution in the USP (United States Pharmacopeia) Flow Through Apparatus. The mass transfer rate from the vertical planar surface of a compact within the device is examined. The theoretical results obtained are then compared with those of experiment. The paper also examines the effect on the dissolution process caused by the interaction between natural and forced convection within the apparatus and the introduction of additional boundaries.
Compliance with Ethical Standards
Conflict of interests
On behalf of all authors, the corresponding author states that there is no conflict of interest.
- 2.McDonnell D (2012) An analysis of drug dissolution in vivo. Doctoral Thesis. Dublin Institute of Technology, Ireland. https://doi.org/10.21427/D7T011
- 4.United States Pharmacopeia and National Formlary 39-NF34 (2016) The United States Pharmacopeial Convention, Rockwell, MD USAGoogle Scholar
- 13.Squire HB (1938) ‘Modern developments in fluid dynamics’ in S. Goldstein. Oxford University Press, New YorkGoogle Scholar
- 16.Lévêque MA (1928) Les lois de la transmission de chaleur par convection. Ann Mines 13:201Google Scholar