Abstract
Objective: The present study compares the effects of yohimbine, an alpha2 adrenoceptor antagonist, and anetholtrithione, a reference drug in the treatment of dry mouth, in patients treated with psychotropic drugs (tricyclic antidepressants or neuroleptics) and suffering from xerostomia.
Methods: Ten patients were included in a randomized, double-blind, cross-over study, and receiving after yohimbine (3 × 6 mg per day) or anetholtrithione (3 × 25 mg per day) orally for 5 days. Salivary secretion was estimated under resting conditions, before any drug, and then on day 6, 1 h after the ingestion of yohimbine or anetholtrithione.
Results: Compared with basal secretion, the increase in salivary flow was significantly more marked after yohimbine than after anetholtrithione.
Conclusion: This study demonstrates the sialogenic effect of yohimbine in drug-induced dry mouth.
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Received: 23 October 1996 / Accepted in revised form: 22 January 1997
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Bagheri, H., Schmitt, L., Berlan, M. et al. A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs. E J Clin Pharmacol 52, 339–342 (1997). https://doi.org/10.1007/s002280050298
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DOI: https://doi.org/10.1007/s002280050298