Skip to main content
SpringerLink
Log in

Management of enzyme de-induction in a woman with HIV on methadone maintenance switched from nevirapine- to bictegravir-based antiretroviral regimen

  • Correspondence
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data availability

No datasets were generated or analysed during the current study.

References

  1. Iribarne C, Berthou F, Baird S, Dréano Y, Picart D, Bail JP et al (1996) Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol 9:365–373

    Article  CAS  PubMed  Google Scholar 

  2. Heelon MW, Meade LB (1999) Methadone withdrawal when starting an antiretroviral regimen including NVP. Pharmacotherapy 19:471–472

    Article  CAS  PubMed  Google Scholar 

  3. Otero MJ, Fuertes A, Sanchez R, Luna G (1999) Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert. AIDS 13:1004–1005

    Article  CAS  PubMed  Google Scholar 

  4. Altice FL, Friedland GH, Cooney EL (1999) Nevirapine-induced opiate withdrawal among injection drug users with HIV infection receiving methadone. AIDS 13:957–962

    Article  CAS  PubMed  Google Scholar 

  5. Bettonte S, Berton M, Stader F, Battegay M, Marzolini C (2023) Management of drug interactions with Inducers: onset and disappearance of induction on cytochrome P450 3A4 and uridine diphosphate glucuronosyltransferase 1A1 substrates. Eur J Drug Metab Pharmacokinet 48:353–362

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Podany AT, Scarsi KK, Pham MM, Fletcher CV (2020) Comparative clinical pharmacokinetics and pharmacodynamics of HIV-1 integrase strand transfer inhibitors: an updated review. Clin Pharmacokinet 59:1085–1107

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Muro E, Droste JAH, Hofstede H, Bosch M, Dolmans W, Burger D (2005) Nevirapine plasma concentrations are still detectable after more than 2 weeks in the majority of women receiving single-dose nevirapine: implications for intervention studies. JAIDS J Acquir Immune Defic Syndr 39:419–421

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Infectious Diseases, ASST Fatebenefratelli Sacco University Hospital, via GB Grassi 74, 20157, Milan, Italy

    Dario Cattaneo, Andrea Giacomelli, Giacomo Casalini, Anna Lisa Ridolfo & Cristina Gervasoni

  2. Gestione Ambulatoriale Politerapie (GAP) Outpatient Clinic, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy

    Dario Cattaneo & Cristina Gervasoni

Authors
  1. Dario Cattaneo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Giacomelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giacomo Casalini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anna Lisa Ridolfo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Cristina Gervasoni
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

D.C., C.G. planned the study, revised the therapies of the patient and wrote the first draft of the manuscript. A.G., G.C., and A.L.R. took care of the patient and performed outpatient visits. This study was carried out as part of our routine work.

Corresponding author

Correspondence to Cristina Gervasoni.

Ethics declarations

Competing interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cattaneo, D., Giacomelli, A., Casalini, G. et al. Management of enzyme de-induction in a woman with HIV on methadone maintenance switched from nevirapine- to bictegravir-based antiretroviral regimen. Eur J Clin Pharmacol (2024). https://doi.org/10.1007/s00228-024-03681-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s00228-024-03681-x

Search

Navigation