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Azam C, Claraz P, Chevreau C, Vinson C, Cottura E, Mourey L, Pouessel D, Guibaud S, Pollet O, Le Goff M, Bardies C, Pelagatti V, Canonge JM, Puisset F (2020) Association between clinically relevant toxicities of pazopanib and sunitinib and the use of weak CYP3A4 and P-gp inhibitors. Eur J Clin Pharmacol 76(4):579–587. https://doi.org/10.1007/s00228-020-02828-w
Pinkhas D, Ho T, Smith S (2017) Assessment of pazopanib-related hypertension, cardiac dysfunction and identification of clinical risk factors for their development. Cardiooncology 3. https://doi.org/10.1186/s40959-017-0024-8
Suttle A, Ball H, Molimard M, Hutson T, Carpenter C, Rajagopalan D, Lin Y, Swann S, Amado R, Pandite L (2014) Relationships between pazopanib exposure and clinical safety and efficacy in patients with advanced renal cell carcinoma. Br J Cancer 111(10):1909–1916
Resteghini C, Cavalieri S, Galbiati D, Granata R, Alfieri S, Bergamini C, Bossi P, Licitra L, Locati LD (2017) Management of tyrosine kinase inhibitors (TKI) side effects in differentiated and medullary thyroid cancer patients. Best Pract Res Clin Endocrinol Metab 31(3):349–361. https://doi.org/10.1016/j.beem.2017.04.012
de Wit D, van Erp NP, den Hartigh J, Wolterbeek R, den Hollander-van Deursen M, Labots M, Guchelaar HJ, Verheul HM, Gelderblom H (2015) Therapeutic drug monitoring to individualize the dosing of pazopanib: a pharmacokinetic feasibility study. Ther Drug Monit 37(3):331–338. https://doi.org/10.1097/ftd.0000000000000141
Teo Y, Wee H, Chue X, Chau N, Tan M, Kanesvaran R, Ho H, Chan A (2016) Effect of the CYP3A5 and ABCB1 genotype on exposure, clinical response and manifestation of toxicities from sunitinib in Asian patients. Pharmacogenomics J 16(1):47–53
Westerdijk K, Desar IM, Steeghs N, van der Graaf WT, van Erp NP, Pharmacology D, Group O (2020) Imatinib, sunitinib and pazopanib: from flat-fixed dosing towards a pharmacokinetically guided personalized dose. Br J Clin Pharmacol 86(2):258–273
Verheijen RB, Beijnen JH, Schellens JHM, Huitema ADR, Steeghs N (2017) Clinical pharmacokinetics and pharmacodynamics of pazopanib: towards optimized dosing. Clin Pharmacokinet 56(9):987–997. https://doi.org/10.1007/s40262-017-0510-z
Santoni M, Conti A, Massari F, Arnaldi G, Iacovelli R, Rizzo M, De Giorgi U, Trementino L, Procopio G, Tortora G, Cascinu S (2015) Treatment-related fatigue with sorafenib, sunitinib and pazopanib in patients with advanced solid tumors: an up-to-date review and meta-analysis of clinical trials. Int J Cancer 136(1):1–10. https://doi.org/10.1002/ijc.28715
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Sadeghi, S., Kargar, M. Is there association between clinically relevant toxicities of pazopanib and sunitinib with the use of weak CYP3A4 and P-gp inhibitors?. Eur J Clin Pharmacol 77, 1427–1428 (2021). https://doi.org/10.1007/s00228-021-03118-9
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DOI: https://doi.org/10.1007/s00228-021-03118-9