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Liver injury during rivaroxaban treatment in a patient with AL amyloidosis

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References

  1. Song AB, Rosovsky RP, Connors JM, Al-Samkari H (2019) Direct oral anticoagulants for treatment and prevention of venous thromboembolism in cancer patients. Vasc Health Risk Manag 15:175–186. Published 2019 Jun 21. https://doi.org/10.2147/VHRM.S132556

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Grandoni F, Alberio L (2019) Direct oral anticoagulant drugs: on the treatment of cancer-related venous thromboembolism and their potential anti-neoplastic effect. Cancers (Basel) 11(1):46. Published 2019 Jan 5. https://doi.org/10.3390/cancers11010046

    Article  CAS  Google Scholar 

  3. Al-Samkari H, Connors JM (2018) The role of direct oral anticoagulants in treatment of cancer-associated thrombosis. Cancers (Basel) 10(8):271. Published 2018 Aug 15. https://doi.org/10.3390/cancers10080271

    Article  CAS  Google Scholar 

  4. Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D et al (2018) Edoxaban for the treatment of cancer-associated venous thromboembolism. N Engl J Med 378(7):615–624. https://doi.org/10.1056/nejmoa1711948

    Article  CAS  PubMed  Google Scholar 

  5. Feng D, Syed IS, Martinez M, Oh JK, Jaffe AS, Grogan M et al (2009) Intracardiac thrombosis and anticoagulation therapy in cardiac amyloidosis. Circulation 119(18):2490–2497. https://doi.org/10.1161/circulationaha.108.785014

    Article  CAS  PubMed  Google Scholar 

  6. European Association for the Study of the Liver (2019) EASL clinical practice guidelines: drug-induced liver injury. J Hepatol 70:1222–1261

    Article  Google Scholar 

  7. Teschke R (2019) Idiosyncratic DILI: analysis of 46,266 cases assessed for causality by RUCAM and published from 2014 to early 2019. Front Pharmacol 23:730

    Article  Google Scholar 

  8. Bjornsson HK, Gudmundsson DO, Bjornsson ES Liver injury caused by oral anticoagulants: a population-based retrospective cohort study. Liver Int 40(8):1895–1900. https://doi.org/10.1111/liv.14559

  9. Yuan L, Kaplowitz N (2013) Mechanisms of drug-induced liver injury. Clin Liver Dis 17(4):507–518. https://doi.org/10.1016/j.cld.2013.07.002

    Article  PubMed  PubMed Central  Google Scholar 

  10. Samiei F, Sajjadi H, Jamshidzadeh A, Seydi E, Pourahmad J (2019) Contrasting role of concentration in rivaroxaban induced toxicity and oxidative stress in isolated kidney mitochondria. Drug Res (Stuttg). 69(10):523–527

    Article  CAS  Google Scholar 

  11. Caldeira D, Barra M, Santos AT, de Abreu D, Pinto FJ, Ferreira JJ, Costa J (2014) Risk of drug-induced liver injury with the new oral anticoagulants: systematic review and meta-analysis. Heart 100(7):550–556. https://doi.org/10.1136/heartjnl-2013-305288

    Article  CAS  PubMed  Google Scholar 

  12. Watkins PB, Desai M, Berkowitz SD et al (2011) Evaluation of drug-induced serious hepatotoxicity (eDISH). Drug-Safety 34:243–252. https://doi.org/10.2165/11586600-000000000-00000

    Article  PubMed  Google Scholar 

  13. LiverTox: clinical and research information on drug-induced liver injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Rivaroxaban. [Updated 2018 Feb 10]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548015/

  14. Peverelle M, Asadi K, Sinclair M (2018) Drug-induced liver failure due to rivaroxaban. Ann Hematol. https://doi.org/10.1007/s00277-018-3364-z

  15. Liakoni E, Rätz Bravo AE, Krähenbühl S (2015) Hepatotoxicity of new oral anticoagulants (NOACs). Drug Saf 38:711–720. https://doi.org/10.1007/s40264-015-0317-5

    Article  CAS  PubMed  Google Scholar 

  16. Russmann S, Niedrig DF, Budmiger M, Schmidt C, Stieger B, Hürlimann S, Kullak-Ublick GA (2014) Rivaroxaban postmarketing risk of liver injury. J Hepatol. https://doi.org/10.1016/j.jhep.2014.03.026

  17. Baig M, Wool KJ, Halanych JH, Sarmad RA (2015) Acute liver failure after initiation of rivaroxaban: a case report and review of the literature. N Am J Med Sci. 7(9):407–410. https://doi.org/10.4103/1947-2714.166221

    Article  PubMed  PubMed Central  Google Scholar 

  18. Epidemiology and individual susceptibility to adverse drug reactions affecting the liver (2002) Larrey D Semin Liver Dis. 22(2):145–155

    Article  Google Scholar 

  19. Shin YM (2011) Hepatic amyloidosis. Korean J Hetatol 17(1):80–83. https://doi.org/10.3350/kjhep.2011.17.1.80

    Article  Google Scholar 

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A.M., L.S., and C.K. collected the data. A.M. and J.Q. analyzed the data. All authors (A.M, L.S., C.K., M.L., S.G., P.M, J.Q.) were involved in writing and reviewing the article.

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Correspondence to Alan Marrinan.

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The authors declare that they have no relevant conflicts of interest.

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Marrinan, A., Shackleton, L., Kelly, C. et al. Liver injury during rivaroxaban treatment in a patient with AL amyloidosis. Eur J Clin Pharmacol 77, 1073–1076 (2021). https://doi.org/10.1007/s00228-020-03084-8

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  • DOI: https://doi.org/10.1007/s00228-020-03084-8

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