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Clinically significant drug-drug interactions between tramadol and CYP3A4 inhibitors: disproportionality analysis in VigiBase® and hypothesis on the underlying mechanism

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Authors and Affiliations

  1. Department of Pharmacology, Caen University Hospital, F-14000, Caen, France

    Clémence Delafoy, Charles Dolladille, Paul Besnier, Marion Sassier, Joanna Bourgine, Véronique Lelong-Boulouard, Joachim Alexandre, Sophie Fedrizzi & Basile Chrétien

  2. Pharmacovigilance Regional Center, Caen University Hospital, F-14000, Caen, France

    Clémence Delafoy, Paul Besnier, Marion Sassier, Sophie Fedrizzi & Basile Chrétien

  3. Signalisation, Électrophysiologie et Imagerie des Lésions d’Ischémie-Reperfusion Myocardique, Normandie University, UNICAEN, Caen University Hospital, 14000, Caen, France

    Charles Dolladille & Joachim Alexandre

  4. COMETE-MOBILITES « Vieillissement, pathologie, santé », Normandie Univ, UNICAEN, UFR Santé, INSERM UMR 1075, 14032, Caen, France

    Véronique Lelong-Boulouard

  5. Department of Pain and Palliative care, Caen University Hospital, F-14000, Caen, France

    Cyril Guillaume

Authors
  1. Clémence Delafoy
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  2. Charles Dolladille
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  3. Paul Besnier
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  4. Marion Sassier
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  5. Joanna Bourgine
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  6. Véronique Lelong-Boulouard
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  7. Joachim Alexandre
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  8. Cyril Guillaume
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  9. Sophie Fedrizzi
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  10. Basile Chrétien
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Corresponding author

Correspondence to Basile Chrétien.

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Delafoy, C., Dolladille, C., Besnier, P. et al. Clinically significant drug-drug interactions between tramadol and CYP3A4 inhibitors: disproportionality analysis in VigiBase® and hypothesis on the underlying mechanism. Eur J Clin Pharmacol 76, 1049–1051 (2020). https://doi.org/10.1007/s00228-020-02881-5

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  • DOI: https://doi.org/10.1007/s00228-020-02881-5

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