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Is cinnarizine/betahistine combination superior to respective monotherapies in treatment of vertigo? Comment on a randomized triple-blind placebo-controlled trial

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References

  1. Asadi P, Zia Ziabari SM, Majdi A, Vatanparast K, Naseri Alavi SA (2019) Cinnarizine/betahistine combination vs. the respective monotherapies in acute peripheral vertigo: a randomized triple-blind placebo-controlled trial. Eur J Clin Pharmacol 75(11):1513–1519. https://doi.org/10.1007/s00228-019-02741-x

    Article  CAS  PubMed  Google Scholar 

  2. Vanderkam P, Blanchard C, Naudet F, Pouchain D, Vaillant Roussel H, Perault-Pochat MC, Jaafari N, Boussageon R (2019) Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials. Eur J Clin Pharmacol 75(5):603–607. https://doi.org/10.1007/s00228-018-02617-6

    Article  CAS  PubMed  Google Scholar 

  3. Murdin L, Hussain K, Schilder AGM (2016) Betahistine for symptoms of vertigo. Cochrane Database Syst Rev 6. https://doi.org/10.1002/14651858.CD010696.pub2

  4. Scholtz AW, Hahn A, Stefflova B, Medzhidieva D, Ryazantsev SV, Paschinin A, Kunelskaya N, Schumacher K, Weisshaar G (2019) Efficacy and safety of a fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg vs betahistine dihydrochloride 16 mg in patients with peripheral vestibular vertigo: a prospective, multinational, multicenter, double-blind, randomized, non-inferiority clinical trial. Clinical drug investigation 39(11):1045–1056. https://doi.org/10.1007/s40261-019-00858-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Cirek Z, Schwarz M, Baumann W, Novotny M (2005) Efficacy and tolerability of a fixed combination of cinnarizine and dimenhydrinate versus betahistine in the treatment of otogenic vertigo : a double-blind, randomised clinical study. Clinical drug investigation 25(6):377–389. https://doi.org/10.2165/00044011-200525060-00003

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Kiumarth Amini

  2. Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, 4th floor, No 92, Karimkhan Zand Ave., Hafte Tir Sq, Tehran, Iran

    Maryam Taghizadeh-Ghehi

Authors
  1. Kiumarth Amini
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  2. Maryam Taghizadeh-Ghehi
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Correspondence to Maryam Taghizadeh-Ghehi.

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Amini, K., Taghizadeh-Ghehi, M. Is cinnarizine/betahistine combination superior to respective monotherapies in treatment of vertigo? Comment on a randomized triple-blind placebo-controlled trial. Eur J Clin Pharmacol 76, 607–608 (2020). https://doi.org/10.1007/s00228-020-02833-z

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  • DOI: https://doi.org/10.1007/s00228-020-02833-z

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