Skip to main content

Advertisement

SpringerLink
Log in

A complex interaction between antitubercular treatment and acenocoumarol

  • Letter to the Editor
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH (2012) Antithrombotic and thrombolytic therapy for valvular disease. Chest 141(2 Suppl):e576S–e600S

    Article  CAS  Google Scholar 

  2. Shibata S, Takahashi H, Baba A, Takeshita K, Atsuda K, Matsubara H, Echizen H (2017) Delayed de-induction of CYP2C9 compared to CYP3A after discontinuation of rifampicin: report of two cases. Int J Clin Pharmacol Ther 55(5):449–452

    Article  Google Scholar 

  3. Thijssen HH, Flinois JP, Beaune PH (2000) Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes. Drug Metab Dispos Biol Fate Chem 28(11):1284–1290

    CAS  PubMed  Google Scholar 

  4. Chen Y, Ferguson SS, Negishi M, Goldstein JA (2004) Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther 308(2):495–501

    Article  CAS  Google Scholar 

  5. Wen X, Wang J-S, Neuvonen PJ, Backman JT (2002) Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes. Eur J Clin Pharmacol 57(11):799–804

    Article  Google Scholar 

  6. Lee SY, Jang H, Lee J-Y, Kwon K, Oh SJ, Kim SK (2014) Inhibition of cytochrome P450 by ethambutol in human liver microsomes. Toxicol Lett 229(1):33–40

    Article  CAS  Google Scholar 

  7. Nishimura Y, Kurata N, Sakurai E, Yasuhara H (2004) Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities. J Pharmacol Sci 96(3):293–300

    Article  CAS  Google Scholar 

  8. George M, Shewade DG, Kumar SV, Adithan C (2012) Effect of anti-tuberculosis therapy on polymorphic drug metabolizing enzyme CYP2C9 using phenytoin as a probe drug. Indian J Pharm 44(4):485–488

    Article  CAS  Google Scholar 

  9. Kay L, Kampmann JP, Svendsen TL, Vergman B, Hansen JE, Skovsted L, Kristensen M (1985) Influence of rifampicin and isoniazid on the kinetics of phenytoin. Br J Clin Pharmacol 20(4):323–326

    Article  CAS  Google Scholar 

  10. Yang J, Liao M, Shou M, Jamei M, Yeo KR, Tucker GT, Rostami-Hodjegan A (2008) Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions. Curr Drug Metab 9(5):384–394

    Article  CAS  Google Scholar 

  11. Harmsze AM, Deneer VHM, Wiltink EH (2007) Prolonged diminished effect of coumarin derivatives after use of rifampicin. Ned Tijdschr Geneeskd 151(35):1945–1949

    CAS  PubMed  Google Scholar 

  12. Michot F, Bürgi M, Büttner J (1970) Rimactan (rifampicin) and anticoagulant therapy. Schweiz Med Wochenschr 100(13):583–584

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India

    Saibal Das, Sapan Kumar Behera, Kirubakaran Ramakrishnan, Mahalakshmi Ganesapandian & Sandhiya Selvarajan

  2. Department of Cardiothoracic and Vascular Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India

    Hemachandren Munuswamy

Authors
  1. Saibal Das
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sapan Kumar Behera
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kirubakaran Ramakrishnan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mahalakshmi Ganesapandian
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hemachandren Munuswamy
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sandhiya Selvarajan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sandhiya Selvarajan.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent of the patient

Informed consent of the patient was obtained for publishing this case report.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Das, S., Behera, S.K., Ramakrishnan, K. et al. A complex interaction between antitubercular treatment and acenocoumarol. Eur J Clin Pharmacol 76, 133–135 (2020). https://doi.org/10.1007/s00228-019-02776-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00228-019-02776-0

Search

Navigation