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IL-2 gene polymorphisms affect tacrolimus response in myasthenia gravis

  • Pharmacogenetics
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Purpose

The IL-2 gene polymorphisms have been reported to be associated with the development of autoimmune disease. However, there are no published studies examining the influence of the IL-2 gene polymorphisms on the response of myasthenia gravis (MG) patients to tacrolimus (Tac). The goal of this study was to investigate the relationship between the polymorphisms of IL-2 and Tac response in MG patients.

Methods

Ninety-two MG patients treated with Tac were studied, including 57 Tac-effective patients and 35 Tac-ineffective patients. Then, we selected four single-nucleotide polymorphisms (SNPs: rs2069776, rs2069772, rs2069762, rs2069763) in the IL-2 gene. Next, we analyzed the distribution of genotypes, allelic frequencies of SNPs, and haplotype frequencies among polymorphisms in the two groups of patients.

Results

The distribution of the allelic frequency of the rs2069762 variant differed between the Tac-effective and Tac-ineffective patients (P = 0.02). Genotypes G/T and G/G of rs2069762 were differently distributed between the two groups when the wild genotype T/T was assigned as a reference (P < 0.001 for G/T; P = 0.003 for G/G). Patients with the TAGG haplotype tended to be Tac-ineffective (P < 0.001, OR: 0.15, 95% CI: 0.05–0.43).

Conclusion

Myasthenia gravis patients with the rs2069762 variant, rs2069762 G/T and G/G genotype, and TAGG haplotype for IL-2 tended to respond poorly to Tac treatment.

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Acknowledgments

The authors acknowledge the support by the nurses affiliated to the Outpatient Clinic of the Department of Neurology in Xiangya Hospital.

Sources of funding

This study was financially supported by grants from the National Nature Science Foundation of China (grant numbers: 8177051973, 81571173 and 81501034).

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Author notes

  1. Yang Shumei, Li Yi, Meng Huanyu, Li Zhibin, Jin Wanlin, Xu Liqun and Yang Huan contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya road, Changsha, Hunan, China

    Yang Shumei, Li Yi, Meng Huanyu, Li Zhibin, Jin Wanlin, Xu Liqun & Yang Huan

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  1. Yang Shumei
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  2. Li Yi
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  3. Meng Huanyu
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  7. Yang Huan
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Correspondence to Yang Huan.

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The study was approved by the Ethics Committee of the Xiangya Hospital of Central South, and all patients provided written informed consent. The certificate number is 201703107.

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The authors declare that they have no conflict of interest.

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Shumei, Y., Yi, L., Huanyu, M. et al. IL-2 gene polymorphisms affect tacrolimus response in myasthenia gravis. Eur J Clin Pharmacol 75, 795–800 (2019). https://doi.org/10.1007/s00228-019-02642-z

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  • DOI: https://doi.org/10.1007/s00228-019-02642-z

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